ID   UWB1.289
AC   CVCL_B079
SY   UWB1-289; UWB1289
DR   BTO; BTO_0006253
DR   ArrayExpress; E-MTAB-3610
DR   ATCC; CRL-2945
DR   BioGRID_ORCS_Cell_line; 1041
DR   BioSample; SAMN03471702
DR   cancercelllines; CVCL_B079
DR   Cell_Model_Passport; SIDM00815
DR   Cosmic-CLP; 1480374
DR   DepMap; ACH-001418
DR   EGA; EGAS00001000978
DR   GDSC; 1480374
DR   GEO; GSM711714
DR   GEO; GSM1291155
DR   GEO; GSM1670568
DR   Lonza; 1665
DR   PharmacoDB; UWB1_289_1650_2019
DR   PRIDE; PXD006939
DR   PRIDE; PXD030304
DR   Wikidata; Q54992390
RX   PubMed=17259345;
RX   PubMed=25230021;
RX   PubMed=27397505;
RX   PubMed=29242379;
RX   PubMed=30894373;
RX   PubMed=30971826;
RX   PubMed=35839778;
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Part of: COSMIC cell lines project.
CC   Part of: OCCP ovarian cancer cell line panel.
CC   Population: Caucasian.
CC   Doubling time: 15.3 hours (PubMed=17259345); ~53 hours (ATCC=CRL-2945).
CC   Microsatellite instability: Stable (MSS) (Sanger).
CC   Sequence variation: Gene deletion; HGNC; HGNC:1100; BRCA1; Zygosity=Heterozygous (PubMed=17259345).
CC   Sequence variation: Mutation; HGNC; HGNC:1100; BRCA1; Simple; p.Asp825Glufs*21 (c.2475delC); ClinVar=VCV000037472; Zygosity=Heterozygous (PubMed=17259345).
CC   Omics: Genomics; DNA methylation analysis.
CC   Omics: Genomics; Whole exome sequencing.
CC   Omics: Phenotyping; CRISPR screening.
CC   Omics: Phenotyping; Drug screening.
CC   Omics: Proteomics; HLA class I peptidome.
CC   Omics: Proteomics; Quantitative.
CC   Omics: Transcriptomics; Microarray.
CC   Genome ancestry: African=0.18%; Native American=0%; East Asian, North=0.95%; East Asian, South=0%; South Asian=1.35%; European, North=70.57%; European, South=26.96% (PubMed=30894373).
ST   Source(s): ATCC=CRL-2945; Cosmic-CLP=1480374; DepMap=ACH-001418; PubMed=25230021
ST   Amelogenin: X
ST   CSF1PO: 11
ST   D13S317: 9
ST   D16S539: 12
ST   D18S51: 19
ST   D19S433: 14,15
ST   D21S11: 28,31
ST   D2S1338: 19
ST   D3S1358: 14,15
ST   D5S818: 13
ST   D7S820: 7,10
ST   D8S1179: 11,12 (DepMap=ACH-001418)
ST   D8S1179: 12 (ATCC=CRL-2945; PubMed=25230021)
ST   FGA: 22
ST   Penta D: 10
ST   Penta E: 8
ST   TH01: 9
ST   TPOX: 9,11
ST   vWA: 16,19
DI   NCIt; C36100; BRCA1 syndrome
DI   ORDO; Orphanet_145; Hereditary breast and ovarian cancer syndrome
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   56Y
CA   Cancer cell line
DT   Created: 06-06-12; Last updated: 10-04-25; Version: 31
CH   CVCL_B078 ! UWB1.289+BRCA1
//
RX   PubMed=17259345; DOI=10.1158/1541-7786.MCR-06-0234;
RA   DelloRusso, Christiana
RA   Welcsh, Piri L.
RA   Wang, Wei-Xin
RA   Garcia, Rochelle L.
RA   King, Mary-Claire
RA   Swisher, Elizabeth M.
RT   "Functional characterization of a novel BRCA1-null ovarian cancer cell
RT   line in response to ionizing radiation.";
RL   Mol. Cancer Res. 5:35-45(2007).
//
RX   PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775;
RA   Goncalves, Emanuel
RA   Poulos, Rebecca C.
RA   Cai, Zhao-Xiang
RA   Barthorpe, Syd
RA   Manda, Srikanth S.
RA   Lucas, Natasha
RA   Beck, Alexandra
RA   Bucio-Noble, Daniel
RA   Dausmann, Michael
RA   Hall, Caitlin
RA   Hecker, Michael
RA   Koh, Jennifer
RA   Lightfoot, Howard
RA   Mahboob, Sadia
RA   Mali, Iman
RA   Morris, James
RA   Richardson, Laura
RA   Seneviratne, Akila J.
RA   Shepherd, Rebecca
RA   Sykes, Erin
RA   Thomas, Frances
RA   Valentini, Sara
RA   Williams, Steven G.
RA   Wu, Yang-Xiu
RA   Xavier, Dylan
RA   MacKenzie, Karen L.
RA   Hains, Peter G.
RA   Tully, Brett
RA   Robinson, Phillip James
RA   Zhong, Qing
RA   Garnett, Mathew J.
RA   Reddel, Roger Robert
RT   "Pan-cancer proteomic map of 949 human cell lines.";
RL   Cancer Cell 40:835-849.e8(2022).
//
RX   PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469;
RA   Iorio, Francesco
RA   Knijnenburg, Theo A.
RA   Vis, Daniel J.
RA   Bignell, Graham Robert
RA   Menden, Michael Patrick
RA   Schubert, Michael
RA   Aben, Nanne
RA   Goncalves, Emanuel
RA   Barthorpe, Syd
RA   Lightfoot, Howard
RA   Cokelaer, Thomas
RA   Greninger, Patricia
RA   van Dyk, Ewald
RA   Chang, Han
RA   de Silva, Heshani
RA   Heyn, Holger
RA   Deng, Xian-Ming
RA   Egan, Regina K.
RA   Liu, Qing-Song
RA   Mironenko, Tatiana
RA   Mitropoulos, Xeni
RA   Richardson, Laura
RA   Wang, Jin-Hua
RA   Zhang, Ting-Hu
RA   Moran, Sebastian
RA   Sayols, Sergi
RA   Soleimani, Maryam
RA   Tamborero, David
RA   Lopez-Bigas, Nuria
RA   Ross-Macdonald, Petra
RA   Esteller, Manel
RA   Gray, Nathanael S.
RA   Haber, Daniel Arie
RA   Stratton, Michael Rudolf
RA   Benes, Cyril Henri
RA   Wessels, Lodewyk F.A.
RA   Saez-Rodriguez, Julio
RA   McDermott, Ultan
RA   Garnett, Mathew J.
RT   "A landscape of pharmacogenomic interactions in cancer.";
RL   Cell 166:740-754(2016).
//
RX   PubMed=25230021; DOI=10.1371/journal.pone.0103988; PMCID=PMC4167545;
RA   Beaufort, Corine M.
RA   Helmijr, Jean C.A.
RA   Piskorz, Anna M.
RA   Hoogstraat, Marlous
RA   Ruigrok-Ritstier, Kirsten
RA   Besselink, Nicolle
RA   Murtaza, Muhammed
RA   van IJcken, Wilfred F.J.
RA   Heine, Anouk A.J.
RA   Smid, Marcel
RA   Koudijs, Marco J.
RA   Brenton, James D.
RA   Berns, Els M.J.J.
RA   Helleman, Jozien
RT   "Ovarian cancer cell line panel (OCCP): clinical importance of in
RT   vitro morphological subtypes.";
RL   PLoS ONE 9:e103988.1-e103988.16(2014).
//
RX   PubMed=30971826; DOI=10.1038/s41586-019-1103-9;
RA   Behan, Fiona M.
RA   Iorio, Francesco
RA   Picco, Gabriele
RA   Goncalves, Emanuel
RA   Beaver, Charlotte M.
RA   Migliardi, Giorgia
RA   Santos, Rita
RA   Rao, Yanhua
RA   Sassi, Francesco
RA   Pinnelli, Marika
RA   Ansari, Rizwan
RA   Harper, Sarah
RA   Jackson, David Adam
RA   McRae, Rebecca
RA   Pooley, Rachel
RA   Wilkinson, Piers
RA   van der Meer, Dieudonne J.
RA   Dow, David
RA   Buser-Doepner, Carolyn A.
RA   Bertotti, Andrea
RA   Trusolino, Livio
RA   Stronach, Euan Alexander
RA   Saez-Rodriguez, Julio
RA   Yusa, Kosuke
RA   Garnett, Mathew J.
RT   "Prioritization of cancer therapeutic targets using CRISPR-Cas9
RT   screens.";
RL   Nature 568:511-516(2019).
//
RX   PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675;
RA   Dutil, Julie
RA   Chen, Zhi-Hua
RA   Monteiro, Alvaro N.A.
RA   Teer, Jamie K.
RA   Eschrich, Steven A.
RT   "An interactive resource to probe genetic diversity and estimated
RT   ancestry in cancer cell lines.";
RL   Cancer Res. 79:1263-1273(2019).
//
RX   PubMed=29242379; DOI=10.1074/mcp.TIR117.000383; PMCID=PMC5836376;
RA   Chong, Chloe
RA   Marino, Fabio
RA   Pak, HuiSong
RA   Racle, Julien
RA   Daniel, Roy Thomas
RA   Muller, Markus
RA   Gfeller, David
RA   Coukos, George
RA   Bassani-Sternberg, Michal
RT   "High-throughput and sensitive immunopeptidomics platform reveals
RT   profound interferon gamma-mediated remodeling of the human leukocyte
RT   antigen (HLA) ligandome.";
RL   Mol. Cell. Proteomics 17:533-548(2018).
//