ID   NM2C5
AC   CVCL_B064
SY   NM-2C5
DR   BTO; BTO_0006144
DR   ATCC; CRL-2918
DR   BioSample; SAMN03151834
DR   cancercelllines; CVCL_B064
DR   Wikidata; Q54930818
RX   PubMed=14506175;
WW   Info; ATCC; -; https://www.atcc.org/en/support/technical-support/faqs/atcc-htb-129-derivative
WW   Info; ICLAC; -; https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx
CC   Problematic cell line: Contaminated. Parent cell line (MDA-MB-435) has been shown to be a M14 derivative.
CC   Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00377.
CC   Population: Caucasian.
CC   Doubling time: 32.24 hours (JWGray panel).
CC   Sequence variation: Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:1787; CDKN2A; Simple; c.150+2T>C (IVS1+2T>C); ClinVar=VCV000406712; Zygosity=Heterozygous; Note=Splice donor mutation (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:1787; CDKN2A; Simple; c.455insCdel26; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Gly266Glu (c.797G>A); ClinVar=VCV000161516; Zygosity=Heterozygous (from parent cell line).
CC   Derived from site: Metastatic; Right buttock, hypodermis; UBERON=UBERON_0013691+UBERON_0002072.
ST   Source(s): ATCC=CRL-2918
ST   Amelogenin: X
ST   CSF1PO: 11
ST   D13S317: 12
ST   D16S539: 13
ST   D18S51: 13,17
ST   D19S433: 14
ST   D21S11: 30
ST   D2S1338: 19,24
ST   D3S1358: 14
ST   D5S818: 11,12
ST   D7S820: 8,10
ST   D8S1179: 13
ST   FGA: 21
ST   Penta D: 9,11
ST   Penta E: 10,12
ST   TH01: 6,7
ST   TPOX: 8,11
ST   vWA: 16,18
DI   NCIt; C3802; Amelanotic melanoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0417 ! MDA-MB-435
SX   Male
AG   33Y
CA   Cancer cell line
DT   Created: 06-06-12; Last updated: 10-04-25; Version: 32
CH   CVCL_B065 ! NM2C5 GFP
//
RX   PubMed=14506175;
RA   Goodison, Steve
RA   Kawai, Kanji
RA   Hihara, Jun
RA   Jiang, Ping
RA   Yang, Meng
RA   Urquidi, Virginia
RA   Hoffman, Robert M.
RA   Tarin, David
RT   "Prolonged dormancy and site-specific growth potential of cancer cells
RT   spontaneously disseminated from nonmetastatic breast tumors as
RT   revealed by labeling with green fluorescent protein.";
RL   Clin. Cancer Res. 9:3808-3814(2003).
//