ID   MDA-MB-435-LCC15
AC   CVCL_B055
AS   CVCL_1U14
SY   LLC-15MB; LCC15-MB
DR   BioSample; SAMN03151830
DR   cancercelllines; CVCL_B055
DR   Wikidata; Q54904634
RX   PubMed=9637769;
RX   PubMed=10432004;
RX   PubMed=15679051;
RX   PubMed=20143388;
WW   Info; ICLAC; -; https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx
CC   Problematic cell line: Contaminated. Parent cell line (MDA-MB-435) has been shown to be a M14 derivative (PubMed=20143388). Was first thought to originate from the femoral metastasis of a breast carcinoma but was later shown to be contaminated by MDA-MB-435 (PubMed=15679051).
CC   Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00231.
CC   Population: Caucasian.
CC   Sequence variation: Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:1787; CDKN2A; Simple; c.150+2T>C (IVS1+2T>C); ClinVar=VCV000406712; Zygosity=Heterozygous; Note=Splice donor mutation (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:1787; CDKN2A; Simple; c.455insCdel26; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Gly266Glu (c.797G>A); ClinVar=VCV000161516; Zygosity=Heterozygous (from parent cell line).
CC   Derived from site: Metastatic; Right buttock, hypodermis; UBERON=UBERON_0013691+UBERON_0002072.
DI   NCIt; C3802; Amelanotic melanoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0417 ! MDA-MB-435
SX   Male
AG   33Y
CA   Cancer cell line
DT   Created: 06-06-12; Last updated: 10-04-25; Version: 29
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RX   PubMed=20143388; DOI=10.1002/ijc.25242;
RA   Capes-Davis, Amanda
RA   Theodosopoulos, George
RA   Atkin, Isobel
RA   Drexler, Hans Gunther
RA   Kohara, Arihiro
RA   MacLeod, Roderick A.F.
RA   Masters, John R.W.
RA   Nakamura, Yukio
RA   Reid, Yvonne A.
RA   Reddel, Roger Robert
RA   Freshney, Robert Ian
RT   "Check your cultures! A list of cross-contaminated or misidentified
RT   cell lines.";
RL   Int. J. Cancer 127:1-8(2010).
//
RX   PubMed=10432004; DOI=10.1023/A:1006598422203;
RA   Thompson, Erik W.
RA   Sung, Vic
RA   Lavigne, Mark C.
RA   Baumann, Klaus H.
RA   Azumi, Norio
RA   Aaron, Alan Dean
RA   Clarke, Robert
RT   "LCC15-MB: a vimentin-positive human breast cancer cell line from a
RT   femoral bone metastasis.";
RL   Clin. Exp. Metastasis 17:193-204(1999).
//
RX   PubMed=15679051; DOI=10.1007/s10585-004-4117-z;
RA   Thompson, Erik W.
RA   Waltham, Mark C.
RA   Ramus, Susan J.
RA   Hutchins, Anne-Marie
RA   Armes, Jane E.
RA   Campbell, Ian G.
RA   Williams, Elizabeth Deborah
RA   Thompson, Phillip R.
RA   Rae, James M.
RA   Johnson, Michael D.
RA   Clarke, Robert
RT   "LCC15-MB cells are MDA-MB-435: a review of misidentified breast and
RT   prostate cell lines.";
RL   Clin. Exp. Metastasis 21:535-541(2004).
//
RX   PubMed=9637769; DOI=10.1006/excr.1998.4029;
RA   Sung, Vic
RA   Gilles, Christine
RA   Murray, Aoife
RA   Clarke, Robert
RA   Aaron, Alan Dean
RA   Azumi, Norio
RA   Thompson, Erik W.
RT   "The LCC15-MB human breast cancer cell line expresses osteopontin and
RT   exhibits an invasive and metastatic phenotype.";
RL   Exp. Cell Res. 241:273-284(1998).
//