ID   MeWo FOTE 4
AC   CVCL_AZ75
SY   MeWo FOTE 4.0; MeWo-fotemustine 4
DR   cancercelllines; CVCL_AZ75
DR   Wikidata; Q54905341
RX   PubMed=11058868;
RX   PubMed=21475863;
CC   Population: Caucasian.
CC   Selected for resistance to: ChEBI; CHEBI:131848; Fotemustine (Mustophoran).
CC   Sequence variation: Gene deletion; HGNC; 1788; CDKN2B; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 1787; CDKN2A; Simple; p.Arg80Ter (c.237_238CC>TT) (c.237_238delinsTT) (p.Pro94Leu, c.280_281CC>TT); Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 6877; MAPK3; Simple; p.Pro246Ser (c.736C>T); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Gln317Ter (c.949C>T); ClinVar=VCV000450344; Zygosity=Unspecified (from parent cell line).
CC   Derived from site: Metastatic; Lymph node; UBERON=UBERON_0000027.
DI   NCIt; C3510; Cutaneous melanoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0445 ! MeWo
SX   Male
AG   78Y
CA   Cancer cell line
DT   Created: 02-05-16; Last updated: 30-01-24; Version: 12
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RX   PubMed=11058868; DOI=10.1002/1097-0215(20001115)88:4<535::AID-IJC4>3.0.CO;2-V;
RA   Grottke C., Mantwill K., Dietel M., Schadendorf D., Lage H.;
RT   "Identification of differentially expressed genes in human melanoma
RT   cells with acquired resistance to various antineoplastic drugs.";
RL   Int. J. Cancer 88:535-546(2000).
//
RX   PubMed=21475863; DOI=10.3892/mmr_00000134;
RA   Surowiak P., Drag M., Materna V., Dietel M., Lage H.;
RT   "Betulinic acid exhibits stronger cytotoxic activity on the normal
RT   melanocyte NHEM-neo cell line than on drug-resistant and
RT   drug-sensitive MeWo melanoma cell lines.";
RL   Mol. Med. Rep. 2:543-548(2009).
//