ID   S520
AC   CVCL_AX35
SY   Patient 2 cell line
DR   cancercelllines; CVCL_AX35
DR   Cosmic; 1801810
DR   Wikidata; Q54951957
RX   PubMed=15207265;
RX   PubMed=15735744;
RX   PubMed=32642732;
CC   Sequence variation: Gene deletion; HGNC; HGNC:7765; NF1; Zygosity=Heterozygous (PubMed=15207265).
CC   Sequence variation: Gene deletion; HGNC; HGNC:11998; TP53; Zygosity=Heterozygous (PubMed=15207265).
CC   Sequence variation: Mutation; HGNC; HGNC:7765; NF1; Simple; p.Arg440Ter (c.1318C>T); ClinVar=VCV000230673; Zygosity=Heterozygous (PubMed=15207265).
CC   Derived from site: In situ; Shoulder; UBERON=UBERON_0001467.
DI   NCIt; C3798; Malignant peripheral nerve sheath tumor
DI   NCIt; C3273; Neurofibromatosis type 1
DI   ORDO; Orphanet_3148; Malignant peripheral nerve sheath tumor
DI   ORDO; Orphanet_636; Neurofibromatosis type 1
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   35Y
CA   Cancer cell line
DT   Created: 02-05-16; Last updated: 19-12-24; Version: 10
//
RX   PubMed=15207265; DOI=10.1016/j.nbd.2004.01.006;
RA   Frahm S., Mautner V.-F., Brems H., Legius E., Debiec-Rychter M.,
RA   Friedrich R.E., Knoefel W.T., Peiper M., Kluwe L.;
RT   "Genetic and phenotypic characterization of tumor cells derived from
RT   malignant peripheral nerve sheath tumors of neurofibromatosis type 1
RT   patients.";
RL   Neurobiol. Dis. 16:85-91(2004).
//
RX   PubMed=15735744; DOI=10.1038/sj.onc.1208425;
RA   Mashour G.A., Drissel S.N., Frahm S., Farassati F., Martuza R.L.,
RA   Mautner V.-F., Kindler-Rohrborn A., Kurtz A.;
RT   "Differential modulation of malignant peripheral nerve sheath tumor
RT   growth by omega-3 and omega-6 fatty acids.";
RL   Oncogene 24:2367-2374(2005).
//
RX   PubMed=32642732; DOI=10.1093/noajnl/vdz049; PMCID=PMC7317054;
RA   Pemov A., Li H., Presley W., Wallace M.R., Miller D.T.;
RT   "Genetics of human malignant peripheral nerve sheath tumors.";
RL   Neurooncol. Adv. 2:i50-i61(2020).
//