ID   EAM306
AC   CVCL_AV62
SY   THJ-306T
DR   ABM; T8259
DR   cancercelllines; CVCL_AV62
DR   Wikidata; Q54831733
RX   CelloPub=CLPUB00321;
RX   PubMed=25675381;
RX   PubMed=29846633;
RX   PubMed=30737244;
CC   Sequence variation: Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gln61Arg (c.182A>G); ClinVar=VCV000013900; Zygosity=Heterozygous (PubMed=29846633; PubMed=30737244).
CC   Sequence variation: Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Heterozygous; Note=In promoter (PubMed=29846633; PubMed=30737244).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Glu326Ter (c.976G>T); ClinVar=VCV000231815; Zygosity=Unspecified (PubMed=29846633; PubMed=30737244).
CC   Omics: Transcriptomics; Microarray.
CC   Derived from site: In situ; Thyroid gland; UBERON=UBERON_0002046.
ST   Source(s): PubMed=29846633; PubMed=30737244
ST   Amelogenin: X
ST   CSF1PO: 10,13
ST   D13S317: 8,12
ST   D16S539: 12
ST   D18S51: 12,15
ST   D21S11: 28,31.2
ST   D3S1358: 15,18
ST   D5S818: 11
ST   D7S820: 11,12
ST   D8S1179: 14,15
ST   FGA: 21
ST   TH01: 6,9.3
ST   TPOX: 9,11
ST   vWA: 16,17
DI   NCIt; C8054; Thyroid gland follicular carcinoma
DI   ORDO; Orphanet_146; Differentiated thyroid carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   59Y
CA   Cancer cell line
DT   Created: 02-05-16; Last updated: 10-04-25; Version: 15
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RX   CelloPub=CLPUB00321;
RA   Marlow L.A., Rohl S.D., Kennedy G.T., Milosevic D., Grebe S.K.G.,
RA   Reddi H.V., Eberhardt N.L., Morris J.C., Trujillo M.A., McDonough S.J.,
RA   McIver B., Bible K.C., Casler J.D., Smallridge R.C., Copland J.A. 3rd;
RT   "Newly characterized follicular thyroid carcinoma cell lines
RT   demonstrate antitumor synergy in response to combined MEK and AKT
RT   inhibitors.";
RL   (In conference) 82nd annual meeting of the American Thyroid Association; pp.A61-A61; American Thyroid Association; Quebec; Canada (2012).
//
RX   PubMed=25675381; DOI=10.1210/jc.2014-2764; PMCID=PMC4422887;
RA   von Roemeling C.A., Marlow L.A., Pinkerton A.B., Crist A., Miller J.,
RA   Tun H.W., Smallridge R.C., Copland J.A. 3rd;
RT   "Aberrant lipid metabolism in anaplastic thyroid carcinoma reveals
RT   stearoyl CoA desaturase 1 as a novel therapeutic target.";
RL   J. Clin. Endocrinol. Metab. 100:E697-E709(2015).
//
RX   PubMed=29846633; DOI=10.1210/jc.2017-01845; PMCID=PMC6126888;
RA   Marlow L.A., Rohl S.D., Miller J.L., Knauf J.A., Fagin J.A., Ryder M.M.,
RA   Milosevic D., Netzel B.C., Grebe S.K.G., Reddi H.V., Smallridge R.C.,
RA   Copland J.A. 3rd;
RT   "Methodology, criteria, and characterization of patient-matched thyroid
RT   cell lines and patient-derived tumor xenografts.";
RL   J. Clin. Endocrinol. Metab. 103:3169-3182(2018).
//
RX   PubMed=30737244; DOI=10.1158/1078-0432.CCR-18-2953; PMCID=PMC6522280;
RA   Landa I., Pozdeyev N., Korch C.T., Marlow L.A., Smallridge R.C.,
RA   Copland J.A. 3rd, Henderson Y.C., Lai S.Y., Clayman G.L., Onoda N.,
RA   Tan A.-C., Garcia-Rendueles M.E.R., Knauf J.A., Haugen B.R.,
RA   Fagin J.A., Schweppe R.E.;
RT   "Comprehensive genetic characterization of human thyroid cancer cell
RT   lines: a validated panel for preclinical studies.";
RL   Clin. Cancer Res. 25:3141-3151(2019).
//