ID   MPNST-724
AC   CVCL_AU20
SY   MPNST724
DR   DepMap; ACH-002710
DR   Wikidata; Q54906510
RX   PubMed=19890883;
RX   PubMed=21084276;
RX   PubMed=25878149;
RX   PubMed=32642732;
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Doubling time: ~24 hours (PubMed=21084276).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; c.280delTCA; Zygosity=Unspecified (PubMed=21084276).
CC   Omics: Transcriptomics; Microarray.
DI   NCIt; C3798; Malignant peripheral nerve sheath tumor
DI   ORDO; Orphanet_3148; Malignant peripheral nerve sheath tumor
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Sex unspecified
AG   Age unspecified
CA   Cancer cell line
DT   Created: 02-05-16; Last updated: 10-04-25; Version: 10
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RX   PubMed=19890883; DOI=10.1002/path.2633; PMCID=PMC4058327;
RA   Subramanian S., Thayanithy V., West R.B., Lee C.-H., Beck A.H., Zhu S.,
RA   Downs-Kelly E., Montgomery K.D., Goldblum J.R., Hogendoorn P.C.W.,
RA   Corless C.L., Oliveira A.M., Dry S.M., Nielsen T.O., Rubin B.P.,
RA   Fletcher J.A., Fletcher C.D.M., van de Rijn M.;
RT   "Genome-wide transcriptome analyses reveal p53 inactivation mediated
RT   loss of miR-34a expression in malignant peripheral nerve sheath
RT   tumours.";
RL   J. Pathol. 220:58-70(2010).
//
RX   PubMed=21084276; DOI=10.1158/0008-5472.CAN-10-2799; PMCID=PMC3064267;
RA   Lopez G., Torres K.E., Liu J.J.-H., Hernandez B., Young E.D., Belousov R.,
RA   Bolshakov S.V., Lazar A.J.F., Slopis J.M., McCutcheon I.E., McConkey D.J.,
RA   Lev D.C.;
RT   "Autophagic survival in resistance to histone deacetylase inhibitors:
RT   novel strategies to treat malignant peripheral nerve sheath tumors.";
RL   Cancer Res. 71:185-196(2011).
//
RX   PubMed=25878149; DOI=10.1158/0008-5472.CAN-15-0675;
RA   Lopez G., Torres K.E., Liu J.J.-H., Hernandez B., Young E.D., Belousov R.,
RA   Bolshakov S.V., Lazar A.J.F., Slopis J.M., McCutcheon I.E., McConkey D.J.,
RA   Lev D.C.;
RT   "Correction: Autophagic survival in resistance to histone deacetylase
RT   inhibitors: novel strategies to treat malignant peripheral nerve
RT   sheath tumors.";
RL   Cancer Res. 75:1771-1774(2015).
//
RX   PubMed=32642732; DOI=10.1093/noajnl/vdz049; PMCID=PMC7317054;
RA   Pemov A., Li H., Presley W., Wallace M.R., Miller D.T.;
RT   "Genetics of human malignant peripheral nerve sheath tumors.";
RL   Neurooncol. Adv. 2:i50-i61(2020).
//