ID   LA-350
AC   CVCL_AR50
SY   LA 350; LA350
DR   Wikidata; Q54901865
RX   PubMed=1643757;
RX   PubMed=2827896;
RX   PubMed=3033590;
RX   PubMed=3257418;
CC   From: Seeger, Robert C.; UCLA Center for Health Sciences; Los Angeles; USA.
CC   Characteristics: Secretes IgM kappa.
CC   Doubling time: 12-18 hours (PubMed=3033590).
CC   Transformant: NCBI_TaxID; 10376; Epstein-Barr virus (EBV).
CC   Miscellaneous: On the basis that LA-350 and LA-N-5 (Cellosaurus=CVCL_0389) are both established by Seeger R.C., that they share identical STR profiles and that LA-350 is said to originate from a patient suffering from neuroblastoma we have annotated them as being autologous cell lines.
CC   Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
ST   Source(s): COG
ST   Amelogenin: X,Y
ST   CSF1PO: 10,11
ST   D13S317: 9,12
ST   D16S539: 9,12
ST   D18S51: 17,22
ST   D19S433: 13,15
ST   D21S11: 29,31
ST   D2S1338: 19,25
ST   D3S1358: 15,16
ST   D5S818: 11
ST   D7S820: 10
ST   D8S1179: 11,13
ST   FGA: 21,27
ST   TH01: 6,9.3
ST   TPOX: 8
ST   vWA: 15,16
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
OI   CVCL_0389 ! LA-N-5
SX   Male
AG   4M
CA   Transformed cell line
DT   Created: 02-05-16; Last updated: 10-09-24; Version: 9
//
RX   PubMed=2827896; DOI=10.1016/0008-8749(88)90095-0;
RA   Shearer, William Thomas
RA   Gilliam, Ellen B.
RA   Rosenblatt, Howard M.
RA   Orson, Frank McNair
RT   "I. Anti-mu antibody stimulates the phosphatidylinositol cycle and
RT   immunoglobulin secretion in a human lymphoblastoid B-cell line,
RT   LA350.";
RL   Cell. Immunol. 111:296-315(1988).
//
RX   PubMed=3257418; DOI=10.1016/0008-8749(88)90096-2;
RA   Shearer, William Thomas
RA   Gilliam, Ellen B.
RA   Rosenblatt, Howard M.
RA   Barron, Karyl S.
RA   Orson, Frank McNair
RT   "II. Phorbol ester binding to a human lymphoblastoid B-cell line, LA350,
RT   stimulates 32P incorporation into selected phospholipids and
RT   immunoglobulin secretion.";
RL   Cell. Immunol. 111:316-331(1988).
//
RX   PubMed=1643757; DOI=10.1016/0090-1229(92)90205-3;
RA   Renz, Harald
RA   Or, Reuven
RA   Domenico, Joanne
RA   Leung, Donald Y.M.
RA   Gelfand, Erwin William
RT   "Reciprocal regulatory effects of IL-4 on cell growth and
RT   immunoglobulin production in Ig-secreting human B-cell lines.";
RL   Clin. Immunol. Immunopathol. 64:233-241(1992).
//
RX   PubMed=3033590; DOI=10.1203/00006450-198704000-00003;
RA   Rosenblatt, Howard M.
RA   Lewis, Dorothy E.
RA   Sklar, Jeffrey
RA   Cleary, Michael L.
RA   Parikh, Nirmi
RA   Galili, Naomi
RA   Ritz, Jerome
RA   Shearer, William Thomas
RT   "Epstein-Barr virus-transformed B-cell line (DV-1) derived from bone
RT   marrow of a patient with severe combined immunodeficiency and
RT   immunoblastic lymphoma.";
RL   Pediatr. Res. 21:331-337(1987).
//