ID   CTSC#432
AC   CVCL_A9WU
SY   CRC-SC#432; CSC22
DR   cancercelllines; CVCL_A9WU
DR   Wikidata; Q102113748
RX   PubMed=26956206;
RX   PubMed=27286453;
RX   PubMed=33128777;
CC   Group: Cancer stem cell line.
CC   From: Sant Andrea Hospital; Rome; Italy.
CC   Microsatellite instability: Stable (MSS) (PubMed=33128777).
CC   Sequence variation: Mutation; HGNC; 2514; CTNNB1; Simple; p.Arg486His (c.1457G>A); ClinVar=VCV000809472; Zygosity=Unspecified (PubMed=33128777).
CC   Sequence variation: Mutation; HGNC; 6407; KRAS; Simple; p.Ala146Thr (c.436G>A); ClinVar=VCV000197243; Zygosity=Unspecified (PubMed=33128777).
CC   Sequence variation: Mutation; HGNC; 11641; TCF7L2; Simple; p.Pro300Leu (c.899C>T); Zygosity=Unspecified (PubMed=33128777).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Val272Leu (c.814G>T); ClinVar=VCV000012358; Zygosity=Unspecified (PubMed=33128777).
CC   Derived from site: In situ; Colon, distal; UBERON=UBERON_0008971.
ST   Source(s): PubMed=33128777
ST   Amelogenin: X,Y
ST   CSF1PO: 10,11
ST   D13S317: 10,12
ST   D16S539: 13
ST   D5S818: 10,13
ST   D7S820: 10,12
ST   TH01: 8,9.3
ST   TPOX: 8
ST   vWA: 17,18
DI   NCIt; C4349; Colon adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   49Y
CA   Cancer cell line
DT   Created: 29-10-20; Last updated: 05-10-23; Version: 7
//
RX   PubMed=26956206; DOI=10.5966/sctm.2015-0214;
RA   De Angelis M.L., Zeuner A., Policicchio E., Russo G., Bruselles A.,
RA   Signore M., Vitale S., De Luca G., Pilozzi E., Boe A., Stassi G.,
RA   Ricci-Vitiani L., Amoreo C.A., Pagliuca A., Francescangeli F.,
RA   Tartaglia M., De Maria R., Baiocchi M.;
RT   "Cancer stem cell-based models of colorectal cancer reveal molecular
RT   determinants of therapy resistance.";
RL   Stem Cells Transl. Med. 5:511-523(2016).
//
RX   PubMed=27286453; DOI=10.18632/oncotarget.9859;
RA   Signore M., Buccarelli M., Pilozzi E., De Luca G., Cappellari M.,
RA   Fanciulli M., Goeman F., Melucci E., Biffoni M., Ricci-Vitiani L.;
RT   "UCN-01 enhances cytotoxicity of irinotecan in colorectal cancer
RT   stem-like cells by impairing DNA damage response.";
RL   Oncotarget 7:44113-44128(2016).
//
RX   PubMed=33128777; DOI=10.1002/ijc.33370;
RA   Visconti P., Parodi F., Parodi B., Casarino L., Romano P.,
RA   Buccarelli M., Pallini R., D'Alessandris Q.G., Montori A., Pilozzi E.,
RA   Ricci-Vitiani L.;
RT   "Short tandem repeat profiling for the authentication of cancer
RT   stem-like cells.";
RL   Int. J. Cancer 148:1489-1498(2021).
//