ID   CTSC#417
AC   CVCL_A9WS
SY   CRC-SC#417
DR   cancercelllines; CVCL_A9WS
DR   Wikidata; Q102113745
RX   PubMed=27286453;
RX   PubMed=33128777;
CC   Group: Cancer stem cell line.
CC   From: Sant Andrea Hospital; Rome; Italy.
CC   Microsatellite instability: Instable (MSI-low) (PubMed=33128777).
CC   Sequence variation: Mutation; HGNC; 583; APC; Simple; p.Met438Thr (c.1313T>C); ClinVar=VCV000630112; Zygosity=Unspecified (PubMed=33128777).
CC   Sequence variation: Mutation; HGNC; 583; APC; Simple; p.Arg876Ter (c.2626C>T); ClinVar=VCV000216014; Zygosity=Unspecified (PubMed=33128777).
CC   Sequence variation: Mutation; HGNC; 8975; PIK3CA; Simple; p.Arg524Lys (c.1571G>A); ClinVar=VCV000132954; Zygosity=Unspecified (PubMed=33128777).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Arg282Trp (c.844C>T); ClinVar=VCV000012364; Zygosity=Unspecified (PubMed=33128777).
CC   Derived from site: In situ; Colon, proximal; UBERON=UBERON_0008972.
ST   Source(s): PubMed=33128777
ST   Amelogenin: X
ST   CSF1PO: 12
ST   D13S317: 11
ST   D16S539: 12
ST   D5S818: 11
ST   D7S820: 11
ST   TH01: 6,8
ST   TPOX: 9
ST   vWA: 16,17
DI   NCIt; C4349; Colon adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   70Y
CA   Cancer cell line
DT   Created: 29-10-20; Last updated: 05-10-23; Version: 7
//
RX   PubMed=27286453; DOI=10.18632/oncotarget.9859;
RA   Signore M., Buccarelli M., Pilozzi E., De Luca G., Cappellari M.,
RA   Fanciulli M., Goeman F., Melucci E., Biffoni M., Ricci-Vitiani L.;
RT   "UCN-01 enhances cytotoxicity of irinotecan in colorectal cancer
RT   stem-like cells by impairing DNA damage response.";
RL   Oncotarget 7:44113-44128(2016).
//
RX   PubMed=33128777; DOI=10.1002/ijc.33370;
RA   Visconti P., Parodi F., Parodi B., Casarino L., Romano P.,
RA   Buccarelli M., Pallini R., D'Alessandris Q.G., Montori A., Pilozzi E.,
RA   Ricci-Vitiani L.;
RT   "Short tandem repeat profiling for the authentication of cancer
RT   stem-like cells.";
RL   Int. J. Cancer 148:1489-1498(2021).
//