ID   GIST226
AC   CVCL_A9M8
SY   GIST-226
DR   cancercelllines; CVCL_A9M8
DR   GEO; GSM2527264
DR   GEO; GSM2527265
DR   GEO; GSM2786734
DR   Wikidata; Q102113882
RX   PubMed=25239608;
RX   PubMed=29866822;
CC   Sequence variation: Mutation; HGNC; HGNC:6342; KIT; Simple; p.Lys550_Trp557del (c.1648_1671del); Zygosity=Heterozygous (PubMed=29866822).
CC   Sequence variation: Mutation; HGNC; HGNC:6342; KIT; Simple; p.Tyr823Asp (c.2467T>G); ClinVar=VCV000376101; Zygosity=Heterozygous (PubMed=29866822).
CC   Omics: Genomics; ChIP-seq; H3K27ac.
CC   Omics: Transcriptomics; RNAseq.
CC   Cell type: Interstitial cell of Cajal; CL=CL_0002088.
DI   NCIt; C3868; Gastrointestinal stromal tumor
DI   ORDO; Orphanet_44890; Gastrointestinal stromal tumor
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
CA   Cancer cell line
DT   Created: 29-10-20; Last updated: 10-04-25; Version: 8
//
RX   PubMed=25239608; DOI=10.1158/1078-0432.CCR-14-1397; PMCID=PMC4233175;
RA   Garner A.P., Gozgit J.M., Anjum R., Vodala S., Schrock A.B., Zhou T.-J.,
RA   Serrano C., Eilers G., Zhu M.-J., Ketzer J., Wardwell S., Ning Y.,
RA   Song Y., Kohlmann A., Wang F., Clackson T., Heinrich M.C.,
RA   Fletcher J.A., Bauer S., Rivera V.M.;
RT   "Ponatinib inhibits polyclonal drug-resistant KIT oncoproteins and
RT   shows therapeutic potential in heavily pretreated gastrointestinal
RT   stromal tumor (GIST) patients.";
RL   Clin. Cancer Res. 20:5745-5755(2014).
//
RX   PubMed=29866822; DOI=10.1073/pnas.1802079115; PMCID=PMC6016782;
RA   Hemming M.L., Lawlor M.A., Zeid R., Lesluyes T., Fletcher J.A.,
RA   Raut C.P., Sicinska E.T., Chibon F., Armstrong S.A., Demetri G.D.,
RA   Bradner J.E.;
RT   "Gastrointestinal stromal tumor enhancers support a transcription
RT   factor network predictive of clinical outcome.";
RL   Proc. Natl. Acad. Sci. U.S.A. 115:E5746-E5755(2018).
//