ID   DU145-Cas9-539
AC   CVCL_A9CI
DR   cancercelllines; CVCL_A9CI
DR   CCRID; 1101HUM-PUMC000539
DR   Wikidata; Q108820168
CC   Population: Caucasian.
CC   Characteristics: Transduced with a Cas9-FLAG-Neo construct.
CC   Sequence variation: Mutation; HGNC; HGNC:1787; CDKN2A; Simple; p.Asp84Tyr (c.250G>T) (p.Arg98Leu, c.293G>T); ClinVar=VCV000376306; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:9884; RB1; Simple; p.Lys715Ter (c.2143A>T); ClinVar=VCV001786615; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11389; STK11; Simple; p.Lys178fs*86 (c.532_536delAAGCC); Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Pro223Leu (c.668C>T); ClinVar=VCV000234214; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Val274Phe (c.820G>T); ClinVar=VCV000376674; Zygosity=Heterozygous (from parent cell line).
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; Q99ZW2; Streptomyces pyogenes Cas9 (Note=With a C-terminal FLAG tag).
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; P00552; Transposon Tn5 neo.
CC   Derived from site: Metastatic; Brain; UBERON=UBERON_0000955.
ST   Source(s): CCRID=1101HUM-PUMC000539
ST   Amelogenin: X,Y
ST   CSF1PO: 10,11
ST   D12S391: 18,21
ST   D13S317: 12,13
ST   D16S539: 11
ST   D18S51: 12
ST   D19S433: 13
ST   D21S11: 30,33,34
ST   D2S1338: 16
ST   D3S1358: 16
ST   D5S818: 10,13
ST   D6S1043: 11
ST   D7S820: 7,11
ST   D8S1179: 13,14
ST   FGA: 22
ST   Penta E: 12,14
ST   TH01: 7
ST   TPOX: 11
ST   vWA: 17,19
DI   NCIt; C4863; Prostate carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0105 ! DU145
SX   Male
AG   69Y
CA   Cancer cell line
DT   Created: 23-09-21; Last updated: 10-04-25; Version: 10
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