ID   LT97
AC   CVCL_A9BJ
SY   LT97-1
DR   cancercelllines; CVCL_A9BJ
DR   IARC_TP53; 25023
DR   Wikidata; Q108820805
RX   DOI=10.25365/thesis.6275;
RX   PubMed=12204677;
RX   PubMed=12714179;
RX   PubMed=17708598;
RX   PubMed=27996158;
CC   Characteristics: Contains 2 subpopulations of cells, one CD44+, the other CD44- (PubMed=17708598).
CC   Doubling time: ~96 hours (DOI=10.25365/thesis.6275).
CC   Sequence variation: Gene deletion; HGNC; HGNC:583; APC; Zygosity=Homozygous (PubMed=12204677).
CC   Sequence variation: Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly13Asp (c.38G>A); ClinVar=VCV000012580; Zygosity=Heterozygous (PubMed=12204677; PubMed=17708598).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Leu257Arg (c.770T>G); ClinVar=VCV000142134; Zygosity=Heterozygous (PubMed=17708598).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; c.1100+30A>T; ClinVar=VCV000810938; Zygosity=Heterozygous (PubMed=17708598).
CC   Miscellaneous: STR profile mentioned in PubMed=27996158 but obtained from personal communication of Schlormann, Wiebke.
CC   Derived from site: In situ; Colon; UBERON=UBERON_0001155.
ST   Source(s): PubMed=27996158
ST   Amelogenin: X
ST   CSF1PO: 8,11
ST   D13S317: 11,13
ST   D16S539: 11
ST   D5S818: 11
ST   D7S820: 8,12
ST   TH01: 7,9.3
ST   TPOX: 8,11
ST   vWA: 14,17
DI   NCIt; C5673; Colorectal adenoma
DI   NCIt; C3339; Familial adenomatous polyposis
DI   ORDO; Orphanet_733; Familial adenomatous polyposis
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   Age unspecified
CA   Cancer cell line
DT   Created: 23-09-21; Last updated: 19-12-24; Version: 9
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RX   DOI=10.25365/thesis.6275;
RA   Koneczny I.;
RT   "Investigating a model cell line for tumour stem cells in colorectal
RT   cancer.";
RL   Thesis MSc (2009); University of Vienna; Vienna; Austria.
//
RX   PubMed=12204677; DOI=10.1016/S0959-8049(02)00158-2;
RA   Richter M., Jurek D., Wrba F., Kaserer K., Wurzer G.,
RA   Karner-Hanusch J., Marian B.;
RT   "Cells obtained from colorectal microadenomas mirror early
RT   premalignant growth patterns in vitro.";
RL   Eur. J. Cancer 38:1937-1945(2002).
//
RX   PubMed=12714179; DOI=10.1016/S0027-5107(03)00012-5;
RA   Schaeferhenrich A., Beyer-Sehlmeyer G., Festag G., Kuechler A.,
RA   Haag N., Weise A., Liehr T., Claussen U., Marian B., Sendt W.,
RA   Scheele J., Pool-Zobel B.L.;
RT   "Human adenoma cells are highly susceptible to the genotoxic action of
RT   4-hydroxy-2-nonenal.";
RL   Mutat. Res. 526:19-32(2003).
//
RX   PubMed=17708598; DOI=10.1002/path.2220;
RA   Schulenburg A., Cech P., Herbacek I., Marian B., Wrba F., Valent P.,
RA   Ulrich-Pur H.;
RT   "CD44-positive colorectal adenoma cells express the potential stem
RT   cell markers musashi antigen (msi1) and ephrin B2 receptor (EphB2).";
RL   J. Pathol. 213:152-160(2007).
//
RX   PubMed=27996158; DOI=10.1002/mc.22606;
RA   Schlormann W., Lamberty J., Lorkowski S., Ludwig D., Mothes H.,
RA   Saupe C., Glei M.;
RT   "Chemopreventive potential of in vitro fermented nuts in LT97 colon
RT   adenoma and primary epithelial colon cells.";
RL   Mol. Carcinog. 56:1461-1471(2017).
//