ID   STBCi004-B-1
AC   CVCL_A8X1
SY   SFC832-03-06 LRRK2WT/WT C47
DR   BioSamples; SAMEA5859478
DR   EBiSC; STBCi004-B-1
DR   ECACC; 66541204
DR   hPSCreg; STBCi004-B-1
DR   Wikidata; Q102114943
RX   PubMed=32359446;
CC   Sequence variation: Mutation; HGNC; 18618; LRRK2; Simple_corrected; p.Gly2019Ser (c.6055G>A); ClinVar=VCV000001940; Zygosity=Heterozygous; Note=By CRISPR/Cas9 (PubMed=32359446).
CC   Discontinued: ECACC; 66541204; true.
CC   Derived from site: In situ; Skin, dermis; UBERON=UBERON_0002067.
CC   Cell type: Fibroblast of skin; CL=CL_0002620.
DI   NCIt; C198605; Parkinson disease 8, autosomal dominant
DI   ORDO; Orphanet_411602; Hereditary late-onset Parkinson disease
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_RB35 ! STBCi004-B
SX   Female
AG   77Y
CA   Induced pluripotent stem cell
DT   Created: 29-10-20; Last updated: 30-01-24; Version: 7
//
RX   PubMed=32359446; DOI=10.1016/j.stemcr.2020.04.001;
RA   Lee H., Flynn R., Sharma I., Haberman E., Carling P.J., Nicholls F.J.,
RA   Stegmann M., Vowles J., Haenseler W., Wade-Martins R., James W.S.,
RA   Cowley S.A.;
RT   "LRRK2 is recruited to phagosomes and co-recruits RAB8 and RAB10 in
RT   human pluripotent stem cell-derived macrophages.";
RL   Stem Cell Reports 14:940-955(2020).
//