ID   SJ-GBM5
AC   CVCL_A8SE
SY   SJ-G5
DR   cancercelllines; CVCL_A8SE
DR   IARC_TP53; 24987
DR   Wikidata; Q108821306
RX   CelloPub=CLPUB00738;
RX   PubMed=8603418;
RX   PubMed=9802058;
RX   PubMed=10402232;
CC   Senescence: Undergoes crisis at approximately passage 35 (CelloPub=CLPUB00738).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Heterozygous (CelloPub=CLPUB00738; PubMed=9802058).
CC   Derived from site: In situ; Brain; UBERON=UBERON_0000955.
DI   NCIt; C9477; Anaplastic astrocytoma
DI   ORDO; Orphanet_251589; Anaplastic astrocytoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
OI   CVCL_C8E7 ! SJ-GBM4
SX   Female
AG   10Y
CA   Finite cell line
DT   Created: 23-09-21; Last updated: 19-12-24; Version: 6
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RX   CelloPub=CLPUB00738;
RA   Nitiss K.C.;
RT   "Oncogenic changes and induction of differentiation in pediatric
RT   astrocytic cell lines.";
RL   Thesis PhD (1997); University of Southern California Los Angeles; Los Angeles; USA.
//
RX   PubMed=8603418;
RA   Danks M.K., Garrett K.E., Marion R.C., Whipple D.O.;
RT   "Subcellular redistribution of DNA topoisomerase I in anaplastic
RT   astrocytoma cells treated with topotecan.";
RL   Cancer Res. 56:1664-1673(1996).
//
RX   PubMed=9802058;
RA   McPake C.R., Tillman D.M., Poquette C.A., George E.O., Houghton J.A.,
RA   Harris L.C.;
RT   "Bax is an important determinant of chemosensitivity in pediatric
RT   tumor cell lines independent of Bcl-2 expression and p53 status.";
RL   Oncol. Res. 10:235-244(1998).
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RX   PubMed=10402232; DOI=10.3892/ijo.15.2.237;
RA   Sharif T.R., Sharif M.;
RT   "Overexpression of protein kinase C epsilon in astroglial brain tumor
RT   derived cell lines and primary tumor samples.";
RL   Int. J. Oncol. 15:237-243(1999).
//