ID   M9-ENL1
AC   CVCL_A8IE
SY   M9 ENL1; M9ENL1
DR   GEO; GSM838434
DR   GEO; GSM838435
DR   GEO; GSM838436
DR   Wikidata; Q107115912
RX   PubMed=22160482;
CC   Characteristics: Expresses a transfected KMT2A-MLLT1 (MLL-ENL) fusion protein. Mimics the features of primary human pro-B cell acute lymphoblastic leukemia (PubMed=22160482).
CC   Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:7132; KMT2A (Note=KMT2A-MLLT1 fusion).
CC   Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:7134; MLLT1 (Note=KMT2A-MLLT1 fusion).
CC   Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P00552; Transposon Tn5 neo.
CC   Transformant: KMT2A-MLLT1.
CC   Omics: Transcriptomics; Microarray.
CC   Derived from site: In situ; Umbilical cord blood; UBERON=UBERON_0012168.
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
AG   <1D
CA   Transformed cell line
DT   Created: 20-05-21; Last updated: 10-04-25; Version: 8
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RX   PubMed=22160482; DOI=10.1182/blood-2011-01-330019;
RA   McDermott S.P., Eppert K., Notta F., Isaac M., Datti A., Al-awar R.,
RA   Wrana J.L., Minden M.D., Dick J.E.;
RT   "A small molecule screening strategy with validation on human leukemia
RT   stem cells uncovers the therapeutic efficacy of kinetin riboside.";
RL   Blood 119:1200-1207(2012).
//