ID   HEK-Blue IL-1R
AC   CVCL_A8CM
DR   Wikidata; Q107115264
WW   https://www.invivogen.com/hek-blue-il1r
CC   Characteristics: Designed to detect bioactive human and mouse IL1A and IL1B by monitoring the activation of the NF-kappaB and AP-1 pathways. In addition, the TNF-alpha, TLR3 and TLR5 responses have been blocked (InvivoGen).
CC   Characteristics: SEAP (secreted ALPP) reporter cell line, in this cell line SEAP is under the control of an IFN-beta minimal promoter fused to 5 NF-kappaB and AP-1-binding sites.
CC   Knockout cell: Method=Not specified; HGNC; 11849; TLR3.
CC   Knockout cell: Method=Not specified; HGNC; 11851; TLR5.
CC   Knockout cell: Method=Not specified; HGNC; 11916; TNFRSF1A.
CC   Knockout cell: Method=Not specified; HGNC; 11917; TNFRSF1B.
CC   Genetic integration: Method=Transfection/transduction; Gene=HGNC; 439; ALPP.
CC   Genetic integration: Method=Transfection/transduction; Gene=MGI; MGI:96545; Il1r1.
CC   Genetic integration: Method=Transfection/transduction; Gene=MGI; MGI:104975; Il1rap.
CC   Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P17493; Streptoalloteichus hindustanus ble (BleoR).
CC   Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P00557; Escherichia coli hygromycin-B 4-O-kinase (hph) (HygR).
CC   Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P13249; S.alboniger pac (PuroR).
CC   Transformant: NCBI_TaxID; 28285; Adenovirus 5.
CC   Derived from site: In situ; Fetal kidney; UBERON=UBERON_0002113.
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_A8CL ! HEK-Blue IL-1beta
SX   Female
AG   Fetus
CA   Transformed cell line
DT   Created: 20-05-21; Last updated: 10-09-24; Version: 7
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