ID   THP1-Blue KI-IP10
AC   CVCL_A8CC
SY   THP1-Blue KI-IP10-Lucia
DR   cancercelllines; CVCL_A8CC
DR   Wikidata; Q107117042
WW   https://www.invivogen.com/thp1-blue-ki-ip10
CC   Population: Japanese.
CC   Characteristics: The coding sequence of CXCL10 has been replaced with the Lucia luciferase reporter gene under the control of the endogenous promoter and thus allows the direct study of CXCL10 induction.
CC   Characteristics: SEAP (secreted ALPP) reporter cell line, in this cell line SEAP is under the control of an IFN-beta minimal promoter fused to 5 copies of the NF-kappaB consensus TRE and 3 copies of the c-Rel binding site.
CC   Knockout cell: Method=Not specified; HGNC; 10637; CXCL10.
CC   Sequence variation: Gene fusion; HGNC; 2457; CSNK2A1 + HGNC; 13917; DDX39B; Name(s)=CSNK2A1-DDX39B (from parent cell line).
CC   Sequence variation: Gene fusion; HGNC; 7132; KMT2A + HGNC; 7136; MLLT3; Name(s)=KMT2A-MLLT3, MLL-MLLT3, MLL-AF9 (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 7989; NRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000039648; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Arg174fs*3 (c.520_545del26); Zygosity=Heterozygous (from parent cell line).
CC   Transfected with: HGNC; 439; ALPP.
CC   Transfected with: Lucia luciferase, a synthetic gene designed on natural secreted luciferase genes from marine copepods.
CC   Transfected with: UniProtKB; P33967; B.cereus Bsr.
CC   Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
DI   NCIt; C9163; Childhood acute monocytic leukemia
DI   ORDO; Orphanet_514; Acute monoblastic/monocytic leukemia
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_X585 ! THP1-Blue NF-kappaB
SX   Male
AG   1Y
CA   Cancer cell line
DT   Created: 20-05-21; Last updated: 05-10-23; Version: 6
//