ID   HepG2-Lucia AhR
AC   CVCL_A8BT
DR   cancercelllines; CVCL_A8BT
DR   InvivoGen; hpgl-ahr
DR   Wikidata; Q107115335
CC   Population: Caucasian.
CC   Characteristics: Used for the study of aryl hydrocarbon receptor (AhR) genomic signaling induction (InvivoGen=hpgl-ahr).
CC   Characteristics: The Lucia luciferase reporter gene is under the control of a minimal promoter coupled with the human CYP1A1 gene entire regulatory sequence which contains 6 dioxin responsive elements (DRE) (InvivoGen=hpgl-ahr).
CC   Sequence variation: Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gln61Leu (c.182A>T); ClinVar=VCV000375874; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
CC   Genetic integration: Method=Transfection; Gene=UniProtKB; P17493; Streptoalloteichus hindustanus ble (BleoR).
CC   Genetic integration: Method=Transfection; Gene=Lucia luciferase (Note=Synthetic gene designed on natural secreted luciferase genes from marine copepods).
CC   Derived from site: In situ; Liver; UBERON=UBERON_0002107.
DI   NCIt; C3728; Hepatoblastoma
DI   ORDO; Orphanet_449; Hepatoblastoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0027 ! Hep-G2
SX   Male
AG   15Y
CA   Cancer cell line
DT   Created: 20-05-21; Last updated: 10-04-25; Version: 10
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