ID   SHSY-5Y Tet-On SNCA
AC   CVCL_A7QJ
SY   SHSY-5Y Tet-On Inducible Alpha-Synuclein
DR   cancercelllines; CVCL_A7QJ
DR   Millipore; SCC291
DR   Wikidata; Q107116922
CC   Population: Caucasian.
CC   Characteristics: Inducible expression of SNCA upon treatment with doxycycline. Serves as a model for both dopaminergic neuronal biology and a-synuclein pathology (Millipore=SCC291).
CC   Characteristics: Transfected with reverse tetracycline-controlled transactivator (rtTA), a fusion between a mutated version of E.coli TetR and the activating domain of HSV-1 VP16.
CC   Sequence variation: Mutation; HGNC; HGNC:427; ALK; Simple; p.Phe1174Leu (c.3522C>A); ClinVar=VCV000217852; Zygosity=Unspecified (from parent cell line).
CC   Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:11138; SNCA.
CC   Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P04483; Escherichia coli Tn10 tetR.
CC   Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P06492; Human herpesvirus 1 VP16 (UL28) (Note=With p.Met1_Arg360del).
CC   Derived from site: Metastatic; Bone marrow; UBERON=UBERON_0002371.
ST   Source(s): Millipore=SCC291
ST   Amelogenin: X
ST   CSF1PO: 11
ST   D13S317: 11
ST   D16S539: 8,13
ST   D18S51: 13,16
ST   D21S11: 31,31.2
ST   D3S1358: 15,16
ST   D5S818: 12
ST   D7S820: 7,10
ST   D8S1179: 15
ST   FGA: 23.2,24
ST   Penta D: 10,12
ST   Penta E: 7,11
ST   TH01: 7,10
ST   TPOX: 8,11
ST   vWA: 14,18
DI   NCIt; C3270; Neuroblastoma
DI   ORDO; Orphanet_635; Neuroblastoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0019 ! SH-SY5Y
SX   Female
AG   4Y
CA   Cancer cell line
DT   Created: 20-05-21; Last updated: 19-12-24; Version: 9
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