ID   NCI-H1975 CS
AC   CVCL_A7EX
DR   cancercelllines; CVCL_A7EX
DR   Wikidata; Q107116538
RX   PubMed=32928921;
CC   Population: Caucasian.
CC   Sequence variation: Mutation; HGNC; 3236; EGFR; Simple; p.Thr790Met (c.2369C>T); ClinVar=VCV000016613; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 3236; EGFR; Simple_edited; p.Cys797Ser (c.2389T>A); ClinVar=VCV000376342; Zygosity=Homozygous; Note=By CRISPR/Cas9 (PubMed=32928921).
CC   Sequence variation: Mutation; HGNC; 3236; EGFR; Simple; p.Leu858Arg (c.2573T>G); ClinVar=VCV000016609; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 8975; PIK3CA; Simple; p.Gly118Asp (c.353G>A); ClinVar=VCV000156446; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Arg273His (c.818G>A); ClinVar=VCV000012366; Zygosity=Homozygous (from parent cell line).
CC   Derived from site: In situ; Lung; UBERON=UBERON_0002048.
DI   NCIt; C3512; Lung adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_1511 ! NCI-H1975
SX   Female
AG   Age unspecified
CA   Cancer cell line
DT   Created: 20-05-21; Last updated: 05-10-23; Version: 4
//
RX   PubMed=32928921; DOI=10.1158/0008-5472.CAN-20-1634;
RA   Sun Y.-T., Meyers B.A., Czako B., Leonard P., Mseeh F., Harris A.L.,
RA   Wu Q., Johnson S., Parker C.A., Cross J.B., Di Francesco M.E.,
RA   Bivona B.J., Bristow C.A., Burke J.P., Carrillo C.C., Carroll C.L.,
RA   Chang Q., Feng N.-P., Gao G., Gera S., Giuliani V., Huang J.K.,
RA   Jiang Y.-Y., Kang Z.-J., Kovacs J.J., Liu C.-Y., Lopez A.M., Ma X.-Y.,
RA   Mandal P.K., McAfoos T., Miller M.A., Mullinax R.A., Peoples M.,
RA   Ramamoorthy V., Seth S., Spencer N.D., Suzuki E., Williams C.C.,
RA   Yu S.S., Zuniga A.M., Draetta G.F., Marszalek J.R., Heffernan T.P.,
RA   Kohl N.E., Jones P.;
RT   "Allosteric SHP2 inhibitor, IACS-13909, overcomes EGFR-dependent and
RT   EGFR-independent resistance mechanisms toward osimertinib.";
RL   Cancer Res. 80:4840-4853(2020).
//