ID   UPN1
AC   CVCL_A795
SY   UPN-1
DR   cancercelllines; CVCL_A795
DR   Cosmic; 1047109
DR   Cosmic; 2296996
DR   GEO; GSM119542
DR   GEO; GSM155075
DR   GEO; GSM155076
DR   GEO; GSM155077
DR   GEO; GSM629500
DR   GEO; GSM629501
DR   GEO; GSM2322623
DR   IARC_TP53; 25020
DR   Progenetix; CVCL_A795
DR   Wikidata; Q54991714
RX   PubMed=12742154;
RX   PubMed=12970738;
RX   PubMed=16960149;
RX   PubMed=17332242;
RX   PubMed=21746927;
RX   PubMed=25688540;
CC   HLA typing: A*24,32; B*07,18; C*07,07 (PubMed=25688540).
CC   Sequence variation: Gene deletion; HGNC; HGNC:9884; RB1; Zygosity=Homozygous (PubMed=17332242).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Glu286Lys (c.856G>A); ClinVar=VCV000183752; Zygosity=Homozygous (PubMed=16960149; PubMed=17332242).
CC   Omics: Transcriptomics; Microarray.
CC   Omics: Variations; Array-based CGH.
CC   Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175.
DI   NCIt; C4337; Mantle cell lymphoma
DI   ORDO; Orphanet_52416; Mantle cell lymphoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   52Y
CA   Cancer cell line
DT   Created: 06-06-12; Last updated: 10-04-25; Version: 20
//
RX   PubMed=16960149; DOI=10.1182/blood-2006-06-026500;
RA   Mestre-Escorihuela, Cinta
RA   Rubio-Moscardo, Fanny
RA   Richter, Jose A.
RA   Siebert, Reiner
RA   Climent, Joan
RA   Fresquet, Vicente
RA   Beltran, Elena
RA   Agirre, Xabier
RA   Marugan, Isabel
RA   Marin, Miguel
RA   Rosenwald, Andreas
RA   Sugimoto, Kei-ji
RA   Wheat, Luise M.
RA   Karran, E. Loraine
RA   Garcia Garcia, Juan Fernando
RA   Sanchez-Verde, Lydia
RA   Prosper, Felipe
RA   Staudt, Louis Michael
RA   Pinkel, Daniel
RA   Dyer, Martin John Swinnerton
RA   Martinez-Climent, Jose Angel
RT   "Homozygous deletions localize novel tumor suppressor genes in B-cell
RT   lymphomas.";
RL   Blood 109:271-280(2007).
//
RX   PubMed=12970738; DOI=10.1038/sj.onc.1206826;
RA   M'kacher, Radhia
RA   Bennaceur-Griscelli, Annelise
RA   Farace, Francoise
RA   Lauge, Anthony
RA   Plassa, Louis Francois
RA   Wittmer-Dupret, Evelyne
RA   Dossou, Julien
RA   Violot, Dominique
RA   Deutsch, Eric
RA   Bourhis, Jean
RA   Stoppa-Lyonnet, Dominique
RA   Ribrag, Vincent
RA   Carde, Patrice
RA   Parmentier, Claude
RA   Bernheim, Alain
RA   Turhan, Ali G.
RT   "Multiple molecular mechanisms contribute to radiation sensitivity in
RT   mantle cell lymphoma.";
RL   Oncogene 22:7905-7912(2003).
//
RX   PubMed=12742154; DOI=10.1016/S0165-4608(02)00823-3;
RA   M'kacher, Radhia
RA   Farace, Francoise
RA   Bennaceur-Griscelli, Annelise
RA   Violot, Dominique
RA   Clausse, Bernard
RA   Dossou, Julien
RA   Valent, Alexander
RA   Parmentier, Claude
RA   Ribrag, Vincent
RA   Bosq, Jacques
RA   Carde, Patrice
RA   Turhan, Ali G.
RA   Bernheim, Alain
RT   "Blastoid mantle cell lymphoma: evidence for nonrandom cytogenetic
RT   abnormalities additional to t(11;14) and generation of a mouse
RT   model.";
RL   Cancer Genet. Cytogenet. 143:32-38(2003).
//
RX   PubMed=25688540; DOI=10.1002/cyto.a.22643;
RA   Maiga, Sophie
RA   Brosseau, Carole
RA   Descamps, Geraldine
RA   Dousset, Christelle
RA   Gomez-Bougie, Patricia
RA   Chiron, David
RA   Menoret, Emmanuelle
RA   Kervoelen, Charlotte
RA   Vie, Henri
RA   Cesbron, Anne
RA   Moreau-Aubry, Agnes
RA   Amiot, Martine
RA   Pellat-Deceunynck, Catherine
RT   "A simple flow cytometry-based barcode for routine authentication of
RT   multiple myeloma and mantle cell lymphoma cell lines.";
RL   Cytometry A 87:285-288(2015).
//
RX   PubMed=17332242; DOI=10.1182/blood-2006-11-057208;
RA   Pinyol, Magda
RA   Bea, Silvia
RA   Pla, Laura
RA   Ribrag, Vincent
RA   Bosq, Jacques
RA   Rosenwald, Andreas
RA   Campo, Elias
RA   Jares, Pedro
RT   "Inactivation of RB1 in mantle-cell lymphoma detected by
RT   nonsense-mediated mRNA decay pathway inhibition and microarray
RT   analysis.";
RL   Blood 109:5422-5429(2007).
//
RX   PubMed=21746927; DOI=10.1073/pnas.1018941108; PMCID=PMC3145731;
RA   Beltran, Elena
RA   Fresquet, Vicente
RA   Martinez-Useros, Javier
RA   Richter-Larrea, Jose A.
RA   Sagardoy, Ainara
RA   Sesma, Izaskun
RA   Almada, Luciana L.
RA   Montes-Moreno, Santiago
RA   Siebert, Reiner
RA   Gesk, Stefan
RA   Calasanz, Maria J.
RA   Malumbres, Raquel
RA   Rieger, Melissa
RA   Prosper, Felipe
RA   Lossos, Izidore S.
RA   Piris, Miguel Angel
RA   Fernandez-Zapico, Martin E.
RA   Martinez-Climent, Jose Angel
RT   "A cyclin-D1 interaction with BAX underlies its oncogenic role and
RT   potential as a therapeutic target in mantle cell lymphoma.";
RL   Proc. Natl. Acad. Sci. U.S.A. 108:12461-12466(2011).
//