ID   PC-7
AC   CVCL_A786
SY   PC 7; PC7
DR   BTO; BTO:0005440
DR   EFO; EFO_0002846
DR   cancercelllines; CVCL_A786
DR   Cosmic; 801573
DR   Cosmic; 844834
DR   Cosmic; 876136
DR   Cosmic; 918000
DR   Cosmic; 946057
DR   Cosmic; 1239895
DR   Cosmic; 2125284
DR   Cosmic; 2668306
DR   IARC_TP53; 11870
DR   Wikidata; Q54938464
RX   DOI=10.5795/jjscc.24.451;
RX   PubMed=758928;
RX   PubMed=1332703;
RX   PubMed=1847845;
RX   PubMed=2168285;
RX   PubMed=3731100;
RX   PubMed=10536175;
RX   PubMed=11005564;
RX   PubMed=16105816;
RX   PubMed=19472407;
RX   PubMed=20557307;
CC   From: Immuno-Biological Laboratories (IBL); Tokyo; Japan.
CC   Population: Japanese.
CC   Sequence variation: Mutation; HGNC; 3236; EGFR; Simple; p.Gly719Ser (c.2155G>A); ClinVar=VCV000016612; Zygosity=Unspecified (PubMed=16105816).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.His214Arg (c.641A>G); ClinVar=VCV000376615; Zygosity=Unspecified (PubMed=10536175; PubMed=20557307).
CC   Derived from site: Metastatic; Lymph node; UBERON=UBERON_0000027.
DI   NCIt; C3512; Lung adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   Age unspecified
CA   Cancer cell line
DT   Created: 06-06-12; Last updated: 05-10-23; Version: 18
//
RX   DOI=10.5795/jjscc.24.451;
RA   Tsumuraya M., Nakajima T., Terasaki T., Kodama T., Shimosato Y.,
RA   Higuchi H., Uei Y.;
RT   "Analysis of LDH isoenzyme patterns in cell lines of the small cell
RT   carcinoma (lung) and retinoblastoma.";
RL   Nihon Rinsho Saibo Gakkai Zasshi 24:451-456(1985).
//
RX   PubMed=758928; DOI=10.1038/bjc.1979.3;
RA   Kinjo M., Oka K., Naito S., Kohga S., Tanaka K., Oboshi S., Hayata Y.,
RA   Yasumoto K.;
RT   "Thromboplastic and fibrinolytic activities of cultured human cancer
RT   cell lines.";
RL   Br. J. Cancer 39:15-23(1979).
//
RX   PubMed=1332703; DOI=10.1016/0006-291X(92)91094-7;
RA   Kubota N., Kanzawa F., Nishio K., Takeda Y., Ohmori T., Fujiwara Y.,
RA   Terashima Y., Saijo N.;
RT   "Detection of topoisomerase I gene point mutation in CPT-11 resistant
RT   lung cancer cell line.";
RL   Biochem. Biophys. Res. Commun. 188:571-577(1992).
//
RX   PubMed=1847845; DOI=10.1007/BF00685110;
RA   Sasaki Y., Shinkai T., Eguchi K., Tamura T., Ohe Y., Ohmori T.,
RA   Saijo N.;
RT   "Prediction of the antitumor activity of new platinum analogs based on
RT   their ex vivo pharmacodynamics as determined by bioassay.";
RL   Cancer Chemother. Pharmacol. 27:263-270(1991).
//
RX   PubMed=2168285;
RA   Kanzawa F., Sugimoto Y., Minato K., Kasahara K., Bungo M.,
RA   Nakagawa K., Fujiwara Y., Liu L.F., Saijo N.;
RT   "Establishment of a camptothecin analogue (CPT-11)-resistant cell line
RT   of human non-small cell lung cancer: characterization and mechanism of
RT   resistance.";
RL   Cancer Res. 50:5919-5924(1990).
//
RX   PubMed=3731100;
RA   Hanai N., Shitara K., Yoshida H.;
RT   "Generation of monoclonal antibodies against human lung squamous cell
RT   carcinoma and adenocarcinoma using mice rendered tolerant to normal
RT   human lung.";
RL   Cancer Res. 46:4438-4443(1986).
//
RX   PubMed=10536175; DOI=10.3892/ijo.15.5.927;
RA   Fujita T., Kiyama M., Tomizawa Y., Kohno T., Yokota J.;
RT   "Comprehensive analysis of p53 gene mutation characteristics in lung
RT   carcinoma with special reference to histological subtypes.";
RL   Int. J. Oncol. 15:927-934(1999).
//
RX   PubMed=11005564; DOI=10.1038/sj.neo.7900094;
RA   Kohno T., Sato T., Takakura S., Takei K., Inoue K., Nishioka M.,
RA   Yokota J.;
RT   "Mutation and expression of the DCC gene in human lung cancer.";
RL   Neoplasia 2:300-305(2000).
//
RX   PubMed=16105816; DOI=10.1158/0008-5472.CAN-05-0331;
RA   Nagai Y., Miyazawa H., Huqun X., Tanaka T., Udagawa K., Kato M.,
RA   Fukuyama S., Yokote A., Kobayashi K., Kanazawa M., Hagiwara K.;
RT   "Genetic heterogeneity of the epidermal growth factor receptor in
RT   non-small cell lung cancer cell lines revealed by a rapid and
RT   sensitive detection system, the peptide nucleic acid-locked nucleic
RT   acid PCR clamp.";
RL   Cancer Res. 65:7276-7282(2005).
//
RX   PubMed=19472407; DOI=10.1002/humu.21028;
RA   Blanco R., Iwakawa R., Tang M.-Y., Kohno T., Angulo B., Pio R.,
RA   Montuenga L.M., Minna J.D., Yokota J., Sanchez-Cespedes M.;
RT   "A gene-alteration profile of human lung cancer cell lines.";
RL   Hum. Mutat. 30:1199-1206(2009).
//
RX   PubMed=20557307; DOI=10.1111/j.1349-7006.2010.01622.x;
RA   Iwakawa R., Kohno T., Enari M., Kiyono T., Yokota J.;
RT   "Prevalence of human papillomavirus 16/18/33 infection and p53
RT   mutation in lung adenocarcinoma.";
RL   Cancer Sci. 101:1891-1896(2010).
//