ID   UKRV-Mel-07
AC   CVCL_A706
SY   UKRV-Mel-7; UKRV MEL7
DR   cancercelllines; CVCL_A706
DR   Cosmic; 972285
DR   Cosmic; 1846694
DR   Cosmic; 2686507
DR   Wikidata; Q54990563
RX   PubMed=7646526;
RX   PubMed=10594685;
RX   PubMed=23348503;
CC   Sequence variation: Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gln61Lys (c.181C>A); ClinVar=VCV000073058; Zygosity=Unspecified (PubMed=23348503).
CC   Sequence variation: Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-146C>T (c.250C>T) (C250T); Zygosity=Unspecified; Note=In promoter (PubMed=23348503).
CC   Derived from site: Metastatic; Skin; UBERON=UBERON_0002097.
DI   NCIt; C3224; Melanoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Sex unspecified
AG   Age unspecified
CA   Cancer cell line
DT   Created: 06-06-12; Last updated: 19-12-24; Version: 15
//
RX   PubMed=7646526; DOI=10.1006/bbrc.1995.2187;
RA   Artuc M., Nurnberg W., Czarnetzki B.M., Schadendorf D.;
RT   "Characterization of gene regulatory elements for selective gene
RT   expression in human melanoma cells.";
RL   Biochem. Biophys. Res. Commun. 213:699-705(1995).
//
RX   PubMed=10594685; DOI=10.1046/j.1365-2567.1999.00902.x; PMCID=PMC2326956;
RA   Sun Y.-S., Moller P., Berking C., Schlupen E.-M., Volkenandt M.,
RA   Schadendorf D.;
RT   "In vivo selective expansion of a tumour-specific cytotoxic T-cell
RT   clone derived from peripheral blood of a melanoma patient after
RT   vaccination with gene-modified autologous tumour cells.";
RL   Immunology 98:535-540(1999).
//
RX   PubMed=23348503; DOI=10.1126/science.1230062;
RA   Horn S., Figl A., Rachakonda P.S., Fischer C., Sucker A., Gast A.,
RA   Kadel S., Moll I., Nagore E., Hemminki K., Schadendorf D., Kumar R.;
RT   "TERT promoter mutations in familial and sporadic melanoma.";
RL   Science 339:959-961(2013).
//