ID   N0005 post-immortalized
AC   CVCL_A6RY
SY   N0005(>500); N0005
DR   RCB; RCB2823
DR   Wikidata; Q107116468
RX   PubMed=9365237;
RX   PubMed=9503605;
RX   PubMed=10543396;
RX   PubMed=11520562;
RX   PubMed=12655152;
RX   PubMed=14659045;
RX   PubMed=15150084;
RX   PubMed=15262425;
CC   Population: Japanese.
CC   Karyotypic information: 46,XY,add(3)(p25),add(8)(q24.3),del(17)(p11.2) (PubMed=11520562).
CC   Transformant: NCBI_TaxID; 10376; Epstein-Barr virus (EBV).
CC   Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
ST   Source(s): PubMed=14659045
ST   Amelogenin: X,Y
ST   D16S539: 12
ST   D18S51: 13,19
ST   D19S433: 13,16.2
ST   D21S11: 31
ST   D2S1338: 17,19,20
ST   D3S1358: 16,17
ST   D8S1179: 14
ST   FGA: 20,22
ST   TH01: 6,9
ST   vWA: 15,17
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
OI   CVCL_A6RX ! N0005 pre-immortalized
SX   Male
AG   99Y
CA   Transformed cell line
DT   Created: 20-05-21; Last updated: 29-06-23; Version: 4
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RX   PubMed=9365237; DOI=10.1038/sj.onc.1201377;
RA   Tahara H., Tokutake Y., Maeda S., Kataoka H., Watanabe T., Satoh M.,
RA   Matsumoto T., Sugawara M., Ide T., Goto M., Furuichi Y., Sugimoto M.;
RT   "Abnormal telomere dynamics of B-lymphoblastoid cell strains from
RT   Werner's syndrome patients transformed by Epstein-Barr virus.";
RL   Oncogene 15:1911-1920(1997).
//
RX   PubMed=9503605; DOI=10.1046/j.1432-0436.1998.6240203.x;
RA   Kataoka H., Tahara H., Watanabe T., Sugawara M., Ide T., Goto M.,
RA   Furuichi Y., Sugimoto M.;
RT   "Immortalization of immunologically committed Epstein-Barr
RT   virus-transformed human B-lymphoblastoid cell lines accompanied by a
RT   strong telomerase activity.";
RL   Differentiation 62:203-211(1997).
//
RX   PubMed=10543396; DOI=10.1007/s004399900151;
RA   Goto M., Yamabe Y., Shiratori M., Okada M., Kawabe T., Matsumoto T.,
RA   Sugimoto M., Furuichi Y.;
RT   "Immunological diagnosis of Werner syndrome by down-regulated and
RT   truncated gene products.";
RL   Hum. Genet. 105:301-307(1999).
//
RX   PubMed=11520562; DOI=10.1016/s0165-4608(01)00420-4;
RA   Okubo M., Tsurukubo Y., Higaki T., Kawabe T., Goto M., Murase T.,
RA   Ide T., Furuichi Y., Sugimoto M.;
RT   "Clonal chromosomal aberrations accompanied by strong telomerase
RT   activity in immortalization of human B-lymphoblastoid cell lines
RT   transformed by Epstein-Barr virus.";
RL   Cancer Genet. Cytogenet. 129:30-34(2001).
//
RX   PubMed=12655152; DOI=10.1247/csf.28.61;
RA   Satoh M., Yasuda T., Higaki T., Goto M., Tanuma S.-i., Ide T.,
RA   Furuichi Y., Sugimoto M.;
RT   "Innate apoptosis of human B lymphoblasts transformed by Epstein-Barr
RT   virus: modulation by cellular immortalization and senescence.";
RL   Cell Struct. Funct. 28:61-70(2003).
//
RX   PubMed=14659045; DOI=10.1089/104454903770946700;
RA   Takahashi T., Kawabe T., Okazaki Y., Itoh C., Noda K., Tajima M.,
RA   Satoh M., Goto M., Mitsui Y., Tahara H., Ide T., Furuichi Y.,
RA   Sugimoto M.;
RT   "In vitro establishment of tumorigenic human B-lymphoblastoid cell
RT   lines transformed by Epstein-Barr virus.";
RL   DNA Cell Biol. 22:727-735(2003).
//
RX   PubMed=15150084; DOI=10.1158/0008-5472.CAN-04-0079;
RA   Sugimoto M., Tahara H., Ide T., Furuichi Y.;
RT   "Steps involved in immortalization and tumorigenesis in human
RT   B-lymphoblastoid cell lines transformed by Epstein-Barr virus.";
RL   Cancer Res. 64:3361-3364(2004).
//
RX   PubMed=15262425; DOI=10.1016/j.cancergencyto.2003.11.005;
RA   Sugimoto M., Tahara H., Okubo M., Kobayashi T., Goto M., Ide T.,
RA   Furuichi Y.;
RT   "WRN gene and other genetic factors affecting immortalization of human
RT   B-lymphoblastoid cell lines transformed by Epstein-Barr virus.";
RL   Cancer Genet. Cytogenet. 152:95-100(2004).
//