ID   SCMC-RM2
AC   CVCL_A667
AS   CVCL_UF93
SY   SCMC-RM-2; SCMC-R-2; SCMCRM2; Saitama Children's Medical Center-RhabdoMyosarcoma 2
DR   cancercelllines; CVCL_A667
DR   Cell_Model_Passport; SIDM01346
DR   Cosmic; 687965
DR   Cosmic; 801761
DR   Cosmic; 1037300
DR   Cosmic; 1048113
DR   Cosmic; 1718359
DR   Cosmic; 2355929
DR   DepMap; ACH-001184
DR   GEO; GSM219592
DR   GEO; GSM1012754
DR   JCRB; NIHS0044
DR   Wikidata; Q54952464
RX   CelloPub=CLPUB00110;
RX   CelloPub=CLPUB00599;
RX   DOI=10.2198/sbk.34.289;
RX   PubMed=2323848;
RX   PubMed=18082704;
RX   PubMed=19235922;
RX   PubMed=22142829;
RX   PubMed=23578105;
RX   PubMed=23882450;
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Population: Japanese.
CC   Doubling time: 50 hours (PubMed=2323848).
CC   Sequence variation: Gene fusion; HGNC; 3819; FOXO1 + HGNC; 8617; PAX3; Name(s)=PAX3-FOXO1, PAX3-FKHR; Note=Not found in original tumor (PubMed=23578105; CelloPub=CLPUB00599).
CC   Omics: Deep exome analysis.
CC   Omics: SNP array analysis.
CC   Omics: Transcriptome analysis by microarray.
CC   Misspelling: SCMC-RMZ; PubMed=19235922.
CC   Discontinued: JCRB; NIHS0044; true.
CC   Derived from site: Metastatic; Bone marrow; UBERON=UBERON_0002371.
ST   Source(s): DepMap=ACH-001184
ST   Amelogenin: X
ST   CSF1PO: 12
ST   D13S317: 9,11,12
ST   D16S539: 10,11
ST   D18S51: 11,13
ST   D21S11: 30,33.2
ST   D3S1358: 15,16
ST   D5S818: 11,12
ST   D7S820: 11,12
ST   D8S1179: 14,15
ST   FGA: 19,27
ST   Penta D: 9
ST   Penta E: 11,20,22
ST   TH01: 6,9
ST   TPOX: 8
ST   vWA: 14,18
DI   NCIt; C8971; Embryonal rhabdomyosarcoma
DI   ORDO; Orphanet_99757; Embryonal rhabdomyosarcoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   11Y
CA   Cancer cell line
DT   Created: 06-06-12; Last updated: 02-05-24; Version: 23
//
RX   CelloPub=CLPUB00110;
RA   Hayashi Y., Hanada R., Moriwaki K., Yamamoto K., Imaizumi S.,
RA   Hirata A., Nishida T.;
RT   "Establishment and characterization of cell lines derived from
RT   malignant tumors in children.";
RL   Saitama Shoni Iryo Senta Igaku-shi 8:16-23(1991).
//
RX   CelloPub=CLPUB00599;
RA   Sugimoto T., Kuroda H., Kuwahara Y., Katsumi Y., Misawa A.,
RA   Moritake H., Hosoi H.;
RT   "Cellular and molecular characteristics of established childhood
RT   soft-tissue sarcoma cell lines.";
RL   J. Cancer Res. Therap. Oncol. 7:202.1-202.12(2019).
//
RX   DOI=10.2198/sbk.34.289;
RA   Mizusawa H.;
RT   "Operation of the JCRB cell bank and isoenzyme.";
RL   Seibutsu Butsuri Kagaku 34:289-292(1990).
//
RX   PubMed=2323848; DOI=10.1002/ijc.2910450423;
RA   Hayashi Y., Sugimoto T., Horii Y., Hosoi H., Inazawa J.,
RA   Kemshead J.T., Inaba T., Hanada R., Yamamoto K., Gown A.M., Sawada T.;
RT   "Characterization of an embryonal rhabdomyosarcoma cell line showing
RT   amplification and over-expression of the N-myc oncogene.";
RL   Int. J. Cancer 45:705-711(1990).
//
RX   PubMed=18082704; DOI=10.1016/j.jpedsurg.2007.08.026;
RA   Komuro H., Saihara R., Shinya M., Takita J., Kaneko S., Kaneko M.,
RA   Hayashi Y.;
RT   "Identification of side population cells (stem-like cell population)
RT   in pediatric solid tumor cell lines.";
RL   J. Pediatr. Surg. 42:2040-2045(2007).
//
RX   PubMed=19235922; DOI=10.1002/gcc.20655;
RA   Missiaglia E., Selfe J., Hamdi M., Williamson D., Schaaf G., Fang C.,
RA   Koster J., Summersgill B.M., Messahel B., Versteeg R.,
RA   Pritchard-Jones K., Kool M., Shipley J.M.;
RT   "Genomic imbalances in rhabdomyosarcoma cell lines affect expression
RT   of genes frequently altered in primary tumors: an approach to identify
RT   candidate genes involved in tumor development.";
RL   Genes Chromosomes Cancer 48:455-467(2009).
//
RX   PubMed=22142829; DOI=10.1158/1078-0432.CCR-11-2056; PMCID=PMC3271129;
RA   Shukla N., Ameur N., Yilmaz I., Nafa K., Lau C.-Y., Marchetti A.,
RA   Borsu L., Barr F.G., Ladanyi M.;
RT   "Oncogene mutation profiling of pediatric solid tumors reveals
RT   significant subsets of embryonal rhabdomyosarcoma and neuroblastoma
RT   with mutated genes in growth signaling pathways.";
RL   Clin. Cancer Res. 18:748-757(2012).
//
RX   PubMed=23578105; DOI=10.1111/cas.12173; PMCID=PMC7657110;
RA   Nishimura R., Takita J., Sato-Otsubo A., Kato M., Koh K., Hanada R.,
RA   Tanaka Y., Kato K., Maeda D., Fukayama M., Sanada M., Hayashi Y.,
RA   Ogawa S.;
RT   "Characterization of genetic lesions in rhabdomyosarcoma using a
RT   high-density single nucleotide polymorphism array.";
RL   Cancer Sci. 104:856-864(2013).
//
RX   PubMed=23882450; DOI=10.3389/fonc.2013.00183; PMCID=PMC3713458;
RA   Hinson A.R.P., Jones R., Crose L.E.S., Belyea B.C., Barr F.G.,
RA   Linardic C.M.;
RT   "Human rhabdomyosarcoma cell lines for rhabdomyosarcoma research:
RT   utility and pitfalls.";
RL   Front. Oncol. 3:183.1-183.12(2013).
//