ID   RO-H85-1
AC   CVCL_A666
SY   HRO 85-1
DR   BioSample; SAMN03151606
DR   Wikidata; Q54950798
RX   PubMed=2538133;
RX   PubMed=7736432;
RX   PubMed=23472229;
WW   Info; ICLAC; -; https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx
CC   Problematic cell line: Contaminated. Shown to be a 647V derivative (PubMed=23472229). Originally thought to originate from a thyroid gland medullary carcinoma.
CC   Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00481.
CC   Population: Caucasian.
CC   Sequence variation: Mutation; HGNC; HGNC:3373; EP300; Simple; p.Gln993Ter (c.2977C>T); Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:6974; MDM4; Simple; p.Ser161Ter (c.482C>G); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Ile162Asn (c.485T>A); ClinVar=VCV001408611; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Glu336Ter (c.1006G>T); Zygosity=Heterozygous (from parent cell line).
CC   Derived from site: In situ; Urinary bladder; UBERON=UBERON_0001255.
DI   NCIt; C4912; Bladder carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_1049 ! 647V
SX   Male
AG   59Y
CA   Cancer cell line
DT   Created: 06-06-12; Last updated: 10-04-25; Version: 24
//
RX   PubMed=23472229; DOI=10.1210/jc.2012-4181;
RA   Dadon, Tikva
RA   Ball, Douglas
RA   Nelkin, Barry D.
RT   "Misidentification of putative medullary thyroid cancer cell lines
RT   RO-H85-1 and RO-D81-1.";
RL   J. Clin. Endocrinol. Metab. 98:954-955(2013).
//
RX   PubMed=2538133; DOI=10.1001/archotol.1989.01860280076020;
RA   Abemayor, Elliot
RA   Sidell, Neil
RA   Juillard, Guy Jean-Felix
RT   "Human medullary thyroid carcinoma. Initial characterization and in
RT   vitro differentiation of two new cell lines.";
RL   Arch. Otolaryngol. Head Neck Surg. 115:478-483(1989).
//
RX   PubMed=7736432; DOI=10.1016/0165-4608(94)00185-E;
RA   Cooley, Linda D.
RA   Elder, Frederick F.B.
RA   Knuth, Alexander
RA   Gagel, Robert F.
RT   "Cytogenetic characterization of three human and three rat medullary
RT   thyroid carcinoma cell lines.";
RL   Cancer Genet. Cytogenet. 80:138-149(1995).
//