ID   MZ-CRC-1
AC   CVCL_A656
SY   MZCRC1
DR   cancercelllines; CVCL_A656
DR   Cosmic; 796732
DR   Cosmic; 1239956
DR   Cosmic; 2036698
DR   Cosmic; 2050373
DR   Wikidata; Q54907212
RX   CelloPub=CLPUB00385;
RX   PubMed=7736432;
RX   PubMed=19897677;
RX   PubMed=30737244;
CC   Doubling time: 12-16 days (CelloPub=CLPUB00385).
CC   Sequence variation: Mutation; HGNC; HGNC:4778; H3-4; Simple; p.Arg3Ter (c.7C>T); Zygosity=Heterozygous (PubMed=30737244).
CC   Sequence variation: Mutation; HGNC; HGNC:6913; MAX; Simple; c.295+1G>A; ClinVar=VCV000186993; Zygosity=Homozygous; Note=Splice donor mutation (PubMed=30737244).
CC   Sequence variation: Mutation; HGNC; HGNC:30064; PBRM1; Simple; p.Arg534Ter (c.1600C>T); Zygosity=Homozygous (PubMed=30737244).
CC   Sequence variation: Mutation; HGNC; HGNC:9967; RET; Simple; p.Met918Thr (c.2753T>C); ClinVar=VCV000013919; Zygosity=Heterozygous (PubMed=19897677; PubMed=30737244).
CC   Omics: Transcriptomics; Microarray.
CC   Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
ST   Source(s): PubMed=30737244
ST   Amelogenin: X
ST   CSF1PO: 11
ST   D13S317: 10
ST   D16S539: 10,12
ST   D18S51: 12,17
ST   D21S11: 30
ST   D3S1358: 18
ST   D5S818: 13
ST   D7S820: 11,12
ST   D8S1179: 12,13
ST   FGA: 20
ST   TH01: 7,9.3
ST   TPOX: 11
ST   vWA: 16,17
DI   NCIt; C46099; Hereditary thyroid gland medullary carcinoma
DI   ORDO; Orphanet_99361; Familial medullary thyroid carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   43Y
CA   Cancer cell line
DT   Created: 06-06-12; Last updated: 10-04-25; Version: 22
//
RX   CelloPub=CLPUB00385;
RA   Knuth A., Gabbert H.E., Moll R., Dippold W.G.,
RA   Meyer zum Buschenfelde K.-H.;
RT   "Markers in medullary thyroid cancer established in tissue culture.";
RL   Proc. Am. Assoc. Cancer Res. 28:83.330-83.330(1987).
//
RX   PubMed=7736432; DOI=10.1016/0165-4608(94)00185-E;
RA   Cooley L.D., Elder F.F.B., Knuth A., Gagel R.F.;
RT   "Cytogenetic characterization of three human and three rat medullary
RT   thyroid carcinoma cell lines.";
RL   Cancer Genet. Cytogenet. 80:138-149(1995).
//
RX   PubMed=19897677; DOI=10.1210/jc.2009-1485; PMCID=PMC2805480;
RA   Zhu W., Hai T., Ye L., Cote G.J.;
RT   "Medullary thyroid carcinoma cell lines contain a self-renewing CD133+
RT   population that is dependent on Ret proto-oncogene activity.";
RL   J. Clin. Endocrinol. Metab. 95:439-444(2010).
//
RX   PubMed=30737244; DOI=10.1158/1078-0432.CCR-18-2953; PMCID=PMC6522280;
RA   Landa I., Pozdeyev N., Korch C.T., Marlow L.A., Smallridge R.C.,
RA   Copland J.A. 3rd, Henderson Y.C., Lai S.Y., Clayman G.L., Onoda N.,
RA   Tan A.-C., Garcia-Rendueles M.E.R., Knauf J.A., Haugen B.R.,
RA   Fagin J.A., Schweppe R.E.;
RT   "Comprehensive genetic characterization of human thyroid cancer cell
RT   lines: a validated panel for preclinical studies.";
RL   Clin. Cancer Res. 25:3141-3151(2019).
//