ID   LCSC#1
AC   CVCL_A643
SY   LCSC-1
DR   cancercelllines; CVCL_A643
DR   Cosmic; 946053
DR   Cosmic; 1066160
DR   Cosmic; 1571724
DR   Cosmic; 1656899
DR   Wikidata; Q54902361
RX   PubMed=9416778;
RX   PubMed=16105816;
RX   PubMed=22313637;
CC   Population: Japanese.
CC   Sequence variation: Mutation; HGNC; HGNC:3236; EGFR; Simple; p.Leu858Arg (c.2573T>G); ClinVar=VCV000016609; Zygosity=Unspecified (PubMed=16105816).
DI   NCIt; C3512; Lung adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Sex unspecified
AG   Age unspecified
CA   Cancer cell line
DT   Created: 06-06-12; Last updated: 19-12-24; Version: 12
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RX   PubMed=9416778; DOI=10.1016/S0024-3205(97)01010-2;
RA   Shoji M., Kimura T., Ota K., Yamaji T., Ishibashi M., Ohta M.,
RA   Sasano H., Kawarabayasi Y., Kimura N., Funyu T., Mori T.,
RA   Sahata T.;
RT   "Genotype analysis of prepro-vasopressin signal peptide in
RT   vasopressin-producing and -non-producing lung tumors.";
RL   Life Sci. 61:2561-2566(1997).
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RX   PubMed=16105816; DOI=10.1158/0008-5472.CAN-05-0331;
RA   Nagai Y., Miyazawa H., Hu Q., Tanaka T., Udagawa K., Kato M.,
RA   Fukuyama S., Yokote A., Kobayashi K., Kanazawa M., Hagiwara K.;
RT   "Genetic heterogeneity of the epidermal growth factor receptor in
RT   non-small cell lung cancer cell lines revealed by a rapid and
RT   sensitive detection system, the peptide nucleic acid-locked nucleic
RT   acid PCR clamp.";
RL   Cancer Res. 65:7276-7282(2005).
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RX   PubMed=22313637; DOI=10.4161/cbt.19238;
RA   Takata M., Chikumi H., Miyake N., Adachi K., Kanamori Y., Yamasaki A.,
RA   Igishi T., Burioka N., Nanba E., Shimizu E.;
RT   "Lack of AKT activation in lung cancer cells with EGFR mutation is a
RT   novel marker of cetuximab sensitivity.";
RL   Cancer Biol. Ther. 13:369-378(2012).
//