ID   Isreco-2
AC   CVCL_A628
SY   ISRECO-2; Isreco 2; Isreco2; ISRECO2; IS-2; IS2
DR   cancercelllines; CVCL_A628
DR   ColonAtlas; Isreco2
DR   Cosmic; 711263
DR   Cosmic; 887237
DR   Cosmic; 1479580
DR   IARC_TP53; 6481
DR   Wikidata; Q54898326
RX   PubMed=9000147;
RX   PubMed=9000572;
RX   PubMed=9205061;
RX   PubMed=10766420;
RX   PubMed=11414198;
RX   PubMed=11526487;
RX   PubMed=20570890;
RX   PubMed=24042735;
RX   PubMed=25944804;
CC   Doubling time: 52.52 hours (PubMed=25944804).
CC   Microsatellite instability: Stable (MSS) (PubMed=9000147).
CC   Sequence variation: Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Unspecified (PubMed=20570890).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Tyr163His (c.487T>C); ClinVar=VCV000376680; Zygosity=Unspecified (PubMed=9000147).
CC   Derived from site: Metastatic; Liver; UBERON=UBERON_0002107.
DI   NCIt; C4910; Colon carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
OI   CVCL_A627 ! Isreco-1
OI   CVCL_A629 ! Isreco-3
SX   Sex unspecified
AG   Age unspecified
CA   Cancer cell line
DT   Created: 06-06-12; Last updated: 19-12-24; Version: 22
//
RX   PubMed=24042735; DOI=10.1038/oncsis.2013.35; PMCID=PMC3816225;
RA   Ahmed, Deeqa
RA   Eide, Peter W.
RA   Eilertsen, Ina A.
RA   Danielsen, Stine A.
RA   Eknaes, Mette
RA   Hektoen, Merete
RA   Lind, Guro Elisabeth
RA   Lothe, Ragnhild Adelheid
RT   "Epigenetic and genetic features of 24 colon cancer cell lines.";
RL   Oncogenesis 2:e71.1-e71.8(2013).
//
RX   PubMed=9000147;
RA   Cottu, Paul-Henri
RA   Muzeau, Francoise
RA   Estreicher, Anne
RA   Flejou, Jean-Francois
RA   Iggo, Richard D.
RA   Thomas, Gilles
RA   Hamelin, Richard
RT   "Inverse correlation between RER+ status and p53 mutation in
RT   colorectal cancer cell lines.";
RL   Oncogene 13:2727-2730(1996).
//
RX   PubMed=9205061;
RA   Cajot, Jean-Francois
RA   Sordat, Isabelle
RA   Silvestre, Timothee
RA   Sordat, Bernard
RT   "Differential display cloning identifies motility-related protein
RT   (MRP1/CD9) as highly expressed in primary compared to metastatic human
RT   colon carcinoma cells.";
RL   Cancer Res. 57:2593-2597(1997).
//
RX   PubMed=25944804; DOI=10.1158/1078-0432.CCR-14-2457;
RA   Bazzocco, Sarah
RA   Dopeso, Higinio
RA   Carton-Garcia, Fernando
RA   Macaya, Irati
RA   Andretta, Elena
RA   Chionh, Fiona
RA   Rodrigues, Paulo
RA   Garrido, Miriam
RA   Alazzouzi, Hafid
RA   Nieto, Rocio
RA   Sanchez, Alex
RA   Schwartz, Simo Jr.
RA   Bilic, Josipa
RA   Mariadason, John M.
RA   Arango, Diego
RT   "Highly expressed genes in rapidly proliferating tumor cells as new
RT   targets for colorectal cancer treatment.";
RL   Clin. Cancer Res. 21:3695-3704(2015).
//
RX   PubMed=20570890; DOI=10.1158/0008-5472.CAN-10-0192; PMCID=PMC2943514;
RA   Janakiraman, Manickam
RA   Vakiani, Efsevia
RA   Zeng, Zhao-Shi
RA   Pratilas, Christine A.
RA   Taylor, Barry Stephen
RA   Chitale, Dhananjay
RA   Halilovic, Ensar
RA   Wilson, Manda
RA   Huberman, Kety
RA   Ricarte Filho, Julio Cezar Marques
RA   Persaud, Yogindra
RA   Levine, Douglas A.
RA   Fagin, James Alexander
RA   Jhanwar, Suresh C.
RA   Mariadason, John M.
RA   Lash, Alex
RA   Ladanyi, Marc
RA   Saltz, Leonard B.
RA   Heguy, Adriana
RA   Paty, Philip B.
RA   Solit, David B.
RT   "Genomic and biological characterization of exon 4 KRAS mutations in
RT   human cancer.";
RL   Cancer Res. 70:5901-5911(2010).
//
RX   PubMed=10766420; DOI=10.1016/S0304-3835(99)00401-2;
RA   Schneider, Marlon R.
RA   Hoeflich, Andreas
RA   Fischer, Jurgen R.
RA   Wolf, Eckhard
RA   Sordat, Bernard
RA   Lahm, Harald
RT   "Interleukin-6 stimulates clonogenic growth of primary and metastatic
RT   human colon carcinoma cells.";
RL   Cancer Lett. 151:31-38(2000).
//
RX   PubMed=11526487; DOI=10.1038/sj.onc.1204611;
RA   Gayet, Jacqueline
RA   Zhou, Xiao-Ping
RA   Duval, Alex
RA   Rolland, Sandra
RA   Hoang, Jean-Marc
RA   Cottu, Paul-Henri
RA   Hamelin, Richard
RT   "Extensive characterization of genetic alterations in a series of
RT   human colorectal cancer cell lines.";
RL   Oncogene 20:5025-5032(2001).
//
RX   PubMed=9000572;
RA   Hoang, Jean-Marc
RA   Cottu, Paul-Henri
RA   Thuille, Benedicte
RA   Salmon, Remi J.
RA   Thomas, Gilles
RA   Hamelin, Richard
RT   "BAT-26, an indicator of the replication error phenotype in colorectal
RT   cancers and cell lines.";
RL   Cancer Res. 57:300-303(1997).
//
RX   PubMed=11414198; DOI=10.1007/s004320000207;
RA   Lahm, Harald
RA   Andre, Sabine
RA   Hoeflich, Andreas
RA   Fischer, Jurgen R.
RA   Sordat, Bernard
RA   Kaltner, Herbert
RA   Wolf, Eckhard
RA   Gabius, Hans-Joachim
RT   "Comprehensive galectin fingerprinting in a panel of 61 human tumor
RT   cell lines by RT-PCR and its implications for diagnostic and
RT   therapeutic procedures.";
RL   J. Cancer Res. Clin. Oncol. 127:375-386(2001).
//