ID   NCI-H460/TPT10
AC   CVCL_A5XQ
SY   NCI H460/TPT10
DR   cancercelllines; CVCL_A5XQ
DR   Wikidata; Q107116539
RX   DOI=10.1158/1538-7445.AM2022-1095;
RX   PubMed=33425914;
CC   Population: Caucasian.
CC   Doubling time: 22.46 +- 0.85 hours (PubMed=33425914).
CC   Selected for resistance to: ChEBI; CHEBI:63632; Topotecan.
CC   Sequence variation: Mutation; HGNC; 6407; KRAS; Simple; p.Gln61His (c.183A>T); ClinVar=VCV000045117; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 8975; PIK3CA; Simple; p.Glu545Lys (c.1633G>A); ClinVar=VCV000013655; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11389; STK11; Simple; p.Gln37Ter (c.109C>T); ClinVar=VCV000376334; Zygosity=Homozygous (from parent cell line).
CC   Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
ST   Source(s): PubMed=33425914
ST   Amelogenin: X,Y
ST   CSF1PO: 11,12
ST   D13S317: 13
ST   D16S539: 9
ST   D5S818: 9,10
ST   D7S820: 9
ST   TH01: 9.3
ST   TPOX: 8
ST   vWA: 17
DI   NCIt; C4450; Lung large cell carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0459 ! NCI-H460
SX   Male
AG   Age unspecified
CA   Cancer cell line
DT   Created: 20-05-21; Last updated: 05-10-23; Version: 6
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RX   DOI=10.1158/1538-7445.AM2022-1095;
RA   Teng Q.-X., Lei Z.-N., Zhang W., Fan Y.-F., Wang J.-Q., Cai C.-Y.,
RA   Yang D.-H., Wurpel J.N.D., Chen Z.-S.;
RT   "Establishment and characterization of a topotecan resistant lung
RT   cancer NCI H460/TPT10 cell line and a tumor xenograft model.";
RL   Cancer Res. 82 Suppl. 12:1095-1095(2022).
//
RX   PubMed=33425914; DOI=10.3389/fcell.2020.607275;
RA   Lei Z.-N., Teng Q.-X., Zhang W., Fan Y.-F., Wang J.-Q., Cai C.-Y.,
RA   Lu K.W., Yang D.-H., Wurpel J.N.D., Chen Z.-S.;
RT   "Establishment and characterization of a topotecan resistant non-small
RT   cell lung cancer NCI-H460/TPT10 cell line.";
RL   Front. Cell Dev. Biol. 8:607275.1-607275.10(2020).
//