ID   UM-UC-3 LLWO1
AC   CVCL_A5WS
SY   LLWO1
DR   cancercelllines; CVCL_A5WS
DR   Wikidata; Q107117257
RX   PubMed=12914669;
CC   Population: Caucasian.
CC   Characteristics: Transfected with the plasmid pUHD172-1neo which contains a rtTA under the control of the CMV promoter. The reverse tetracycline-controlled transactivator (rtTA), a fusion between a mutated version of E.coli TetR and the activating domain of HSV-1 VP16 (PubMed=12914669).
CC   Sequence variation: Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Gene deletion; HGNC; 9588; PTEN; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 795; ATM; Simple; p.Gln2800fs*6 (c.8400delG); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 6407; KRAS; Simple; p.Gly12Cys (c.34G>T); ClinVar=VCV000012578; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 14446; PARD3B; Unexplicit; Ex9-18del; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Phe113Cys (c.338T>G); ClinVar=VCV000634690; Zygosity=Unspecified (from parent cell line).
CC   Transfected with: UniProtKB; P00552; Transposon Tn5 neo.
CC   Transfected with: UniProtKB; P04483; Escherichia coli Tn10 tetR.
CC   Transfected with: UniProtKB; P06492; Human herpesvirus 1 VP16 (UL28) (with p.Met1_Arg360del).
CC   Derived from site: In situ; Urinary bladder; UBERON=UBERON_0001255.
DI   NCIt; C4912; Bladder carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_1783 ! UM-UC-3
SX   Male
AG   Age unspecified
CA   Cancer cell line
DT   Created: 20-05-21; Last updated: 05-10-23; Version: 6
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RX   PubMed=12914669; DOI=10.1186/1475-2867-3-12;
RA   Reeder J.E., Sowden M.P., Messing E.M., Klover P., Villa-Moruzzi E.,
RA   Ludlow J.W.;
RT   "Inducible expression of catalytically active type 1 serine/threonine
RT   protein phosphatase in a human carcinoma cell line.";
RL   Cancer Cell Int. 3:12.1-12.12(2003).
//