ID   U-251MG PAX6-/- 2A.28
AC   CVCL_A5TV
SY   PAX6 2A.28 KO
DR   cancercelllines; CVCL_A5TV
DR   Wikidata; Q107117153
RX   PubMed=29716531;
CC   Population: Caucasian.
CC   Knockout cell: Method=CRISPR/Cas9; HGNC; 8620; PAX6.
CC   Sequence variation: Mutation; HGNC; 9588; PTEN; Simple; p.Glu242Valfs*15 (c.723_724dupTG); ClinVar=VCV000536553; Zygosity=Unspecified (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Arg273His (c.818G>A); ClinVar=VCV000012366; Zygosity=Unspecified (from parent cell line).
CC   Derived from site: In situ; Brain, parietal lobe; UBERON=UBERON_0001872.
DI   NCIt; C60781; Astrocytoma
DI   ORDO; Orphanet_94; Astrocytoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0021 ! U-251MG
SX   Male
AG   75Y
CA   Cancer cell line
DT   Created: 20-05-21; Last updated: 05-10-23; Version: 6
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RX   PubMed=29716531; DOI=10.1186/s12885-018-4394-6; PMCID=PMC5930953;
RA   Hegge B., Sjottem E., Mikkola I.;
RT   "Generation of a PAX6 knockout glioblastoma cell line with changes in
RT   cell cycle distribution and sensitivity to oxidative stress.";
RL   BMC Cancer 18:496.1-496.19(2018).
//