ID   COS-F2-130
AC   CVCL_A5QA
DR   Wikidata; Q107114704
RX   PubMed=11356706;
CC   Group: Non-human primate cell line.
CC   Characteristics: Useful system for studying steroidogenesis. Converts cholesterol to pregnenolone but lack downstream enzymes that catalyze other steroidogenic reactions (PubMed=11356706).
CC   Characteristics: Transfected with the F2 construct that consist of the fusion of P450scc-adrenodoxin reductase-adrenodoxin (PubMed=11356706).
CC   Transfected with: HGNC; 2590; CYP11A1.
CC   Transfected with: HGNC; 3638; FDX1.
CC   Transfected with: HGNC; 3642; FDXR.
CC   Transfected with: UniProtKB; P00552; Transposon Tn5 neo.
CC   Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40) [Note=pSV6-1].
CC   Derived from site: In situ; Kidney; UBERON=UBERON_0002113.
OX   NCBI_TaxID=9534; ! Chlorocebus aethiops (Green monkey)
HI   CVCL_0223 ! COS-1
SX   Male
AG   Adult
CA   Transformed cell line
DT   Created: 20-05-21; Last updated: 05-10-23; Version: 5
//
RX   PubMed=11356706; DOI=10.1210/endo.142.6.8206;
RA   Huang M.-C., Miller W.L.;
RT   "Creation and activity of COS-1 cells stably expressing the F2 fusion
RT   of the human cholesterol side-chain cleavage enzyme system.";
RL   Endocrinology 142:2569-2576(2001).
//