ID   CHO-K1 Mev-1
AC   CVCL_A5KD
SY   Mev-1
DR   Wikidata; Q107114656
RX   PubMed=4019518;
RX   PubMed=6118375;
RX   PubMed=7961793;
CC   Characteristics: Deficient for mevalonate biosynthesis. Lacks hydroxymethylglutaryl-CoA synthase activity (PubMed=4019518).
CC   Transformant: ChEBI; CHEBI:23994; Ethyl methanesulfonate (Methylsulfonic acid ethyl ester; MSEE).
CC   Derived from site: In situ; Ovary; UBERON=UBERON_0000992.
CC   Cell type: Epithelial cell of ovary; CL=CL_2000064.
OX   NCBI_TaxID=10029; ! Cricetulus griseus (Chinese hamster)
HI   CVCL_7182 ! CHO Pro-3
SX   Female
AG   Adult
CA   Transformed cell line
DT   Created: 20-05-21; Last updated: 30-01-24; Version: 6
//
RX   PubMed=4019518; DOI=10.1016/S0021-9258(17)39191-3;
RA   Peffley D., Sinensky M.;
RT   "Regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase
RT   synthesis by a non-sterol mevalonate-derived product in Mev-1 cells.
RT   Apparent translational control.";
RL   J. Biol. Chem. 260:9949-9952(1985).
//
RX   PubMed=6118375; DOI=10.1016/S0021-9258(19)68388-2;
RA   Schnitzer-Polokoff R., von Gunten C., Logel J., Torget R.W.,
RA   Sinensky M.;
RT   "Isolation and characterization of a mammalian cell mutant defective
RT   in 3-hydroxy-3-methylglutaryl coenzyme A synthase.";
RL   J. Biol. Chem. 257:472-476(1982).
//
RX   PubMed=7961793; DOI=10.1016/S0021-9258(19)61932-0;
RA   Ortiz J.A., Gil-Gomez G., Casaroli-Marano R.P., Vilaro S.,
RA   Hegardt F.G., Haro D.;
RT   "Transfection of the ketogenic mitochondrial
RT   3-hydroxy-3-methylglutaryl-coenzyme A synthase cDNA into Mev-1 cells
RT   corrects their auxotrophy for mevalonate.";
RL   J. Biol. Chem. 269:28523-28526(1994).
//