ID   Quad-GL261
AC   CVCL_A5EJ
SY   GL261-Quad; GL261-QUAD; GL261-OVA
DR   Wikidata; Q107116683
RX   PubMed=23248259;
RX   PubMed=23686484;
RX   PubMed=24878890;
CC   Characteristics: Transfected with the Quad Ag cassette encoding four peptides presented by H-2b class I or II molecules as a single coding sequence. The peptides are human PMEL/gp100 AA 25-33 (presented by H-2Db), chicken OVA epitope OT-I (AA 258-265; presented by H-2Kb), chicken OVA epitope OT-II (AA 324-340; presented by I-Ab) and mouse H2-Ea/I-Ea AA 77-93(52-68) (presented by I-Ab). To facilitate processing, each peptide is flanked on both sides by the 6 amino acid residues that surrounded the peptide in the corresponding native protein.
CC   Transfected with: HGNC; 10880; PMEL (with p.Met1_Leu18del and p.Arg40_Val661del).
CC   Transfected with: MGI; MGI:95900; H2-Ea (with p.Met1_Leu70del and p.Glu100_Leu255del).
CC   Transfected with: UniProtKB; P01012; Chicken ovalbumin (SERPINB14) (with p.Met1_Ser251del, p.Asn272_Ser317del and p.Glu347_Pro386del).
CC   Transfected with: tdTomato, a bright red fluorescent protein derived from drFP583 (DsRed).
CC   Transfected with: UniProtKB; P00552; Transposon Tn5 neo.
CC   Transformant: ChEBI; CHEBI:34342; 3-methylcholanthrene (3-MC; 20-methylcholanthrene; 20-MC; MCA).
CC   Derived from site: In situ; Brain; UBERON=UBERON_0000955.
CC   Breed/subspecies: C57BL/6.
DI   NCIt; C21938; Mouse glioblastoma
OX   NCBI_TaxID=10090; ! Mus musculus (Mouse)
HI   CVCL_Y003 ! GL261
CA   Cancer cell line
DT   Created: 20-05-21; Last updated: 29-06-23; Version: 6
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RX   PubMed=23248259; DOI=10.4049/jimmunol.1201557;
RA   Ohlfest J.R., Andersen B.M., Litterman A.J., Xia J.-Z., Pennell C.A.,
RA   Swier L.E., Salazar A.M., Olin M.R.;
RT   "Vaccine injection site matters: qualitative and quantitative defects
RT   in CD8 T cells primed as a function of proximity to the tumor in a
RT   murine glioma model.";
RL   J. Immunol. 190:613-620(2013).
//
RX   PubMed=23686484; DOI=10.4049/jimmunol.1203539;
RA   Litterman A.J., Zellmer D.M., Grinnen K.L., Hunt M.A., Dudek A.Z.,
RA   Salazar A.M., Ohlfest J.R.;
RT   "Profound impairment of adaptive immune responses by alkylating
RT   chemotherapy.";
RL   J. Immunol. 190:6259-6268(2013).
//
RX   PubMed=24878890; DOI=10.1007/s00262-014-1561-8;
RA   Kosaka A., Ohkuri T., Okada H.;
RT   "Combination of an agonistic anti-CD40 monoclonal antibody and the
RT   COX-2 inhibitor celecoxib induces anti-glioma effects by promotion of
RT   type-1 immunity in myeloid cells and T-cells.";
RL   Cancer Immunol. Immunother. 63:847-857(2014).
//