ID   NCI-H60
AC   CVCL_A592
SY   H60; H-60
DR   BTO; BTO:0006541
DR   ATCC; CRL-5821
DR   BioSample; SAMN03151862
DR   cancercelllines; CVCL_A592
DR   Cosmic; 1021848
DR   GEO; GSM1682797
DR   Wikidata; Q54908084
RX   PubMed=1563005;
RX   PubMed=2985257;
RX   PubMed=2985258;
RX   PubMed=2986243;
RX   PubMed=6108156;
RX   PubMed=6270685;
RX   PubMed=6272398;
RX   PubMed=6713399;
RX   PubMed=8626706;
RX   PubMed=8806092;
RX   PubMed=8806103;
RX   PubMed=11030152;
RX   PubMed=31803961;
CC   Problematic cell line: Contaminated. Shown to be a NCI-N417 derivative.
CC   Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00416.
CC   Virology: Contains an integrated xenotropic MuLV-related virus (XMRV) Bxv-1 (from parent cell line).
CC   Sequence variation: Gene fusion; HGNC; 23139; CLVS1 + HGNC; 9709; PVT1; Name(s)=PVT1-CLVS1 (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 8975; PIK3CA; Simple; p.Gln546Lys (c.1636C>A); ClinVar=VCV000013657; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Glu298Ter (c.892G>T); ClinVar=VCV000093323; Zygosity=Unspecified (from parent cell line).
CC   Omics: Transcriptome analysis by microarray.
CC   Discontinued: ATCC; CRL-5821; true.
CC   Derived from site: In situ; Lung; UBERON=UBERON_0002048.
ST   Source(s): ATCC=CRL-5821
ST   Amelogenin: X
ST   CSF1PO: 12
ST   D13S317: 10
ST   D16S539: 9
ST   D5S818: 13
ST   D7S820: 11,12
ST   TH01: 6
ST   TPOX: 8
ST   vWA: 17,18
DI   NCIt; C4917; Lung small cell carcinoma
DI   ORDO; Orphanet_70573; Small cell lung cancer
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_1602 ! NCI-N417
SX   Female
AG   Age unspecified
CA   Cancer cell line
DT   Created: 06-06-12; Last updated: 02-05-24; Version: 33
RX   PubMed=1563005;
RA   Giaccone G., Battey J., Gazdar A.F., Oie H.K., Draoui M., Moody T.W.;
RT   "Neuromedin B is present in lung cancer cell lines.";
RL   Cancer Res. 52:2732s-2736s(1992).
RX   PubMed=2985257;
RA   Carney D.N., Gazdar A.F., Bepler G., Guccion J.G., Marangos P.J.,
RA   Moody T.W., Zweig M.H., Minna J.D.;
RT   "Establishment and identification of small cell lung cancer cell lines
RT   having classic and variant features.";
RL   Cancer Res. 45:2913-2923(1985).
RX   PubMed=2985258;
RA   Gazdar A.F., Carney D.N., Nau M.M., Minna J.D.;
RT   "Characterization of variant subclasses of cell lines derived from
RT   small cell lung cancer having distinctive biochemical, morphological,
RT   and growth properties.";
RL   Cancer Res. 45:2924-2930(1985).
RX   PubMed=2986243; DOI=10.1007/978-3-642-82372-5_4;
RA   Whang-Peng J., Lee E.C.;
RT   "Cytogenetics of human small cell lung cancer.";
RL   Recent Results Cancer Res. 97:37-46(1985).
RX   PubMed=6108156;
RA   Gazdar A.F., Carney D.N., Russell E.K., Sims H.L., Baylin S.B.,
RA   Bunn P.A. Jr., Guccion J.G., Minna J.D.;
RT   "Establishment of continuous, clonable cultures of small-cell
RT   carcinoma of lung which have amine precursor uptake and
RT   decarboxylation cell properties.";
RL   Cancer Res. 40:3502-3507(1980).
RX   PubMed=6270685; DOI=10.1073/pnas.78.7.4591;
RA   Cuttitta F., Rosen S.T., Gazdar A.F., Minna J.D.;
RT   "Monoclonal antibodies that demonstrate specificity for several types
RT   of human lung cancer.";
RL   Proc. Natl. Acad. Sci. U.S.A. 78:4591-4595(1981).
RX   PubMed=6272398; DOI=10.1126/science.6272398;
RA   Moody T.W., Pert C.B., Gazdar A.F., Carney D.N., Minna J.D.;
RT   "High levels of intracellular bombesin characterize human small-cell
RT   lung carcinoma.";
RL   Science 214:1246-1248(1981).
RX   PubMed=6713399;
RA   Rosen S.T., Mulshine J.L., Cuttitta F., Fedorko J., Carney D.N.,
RA   Gazdar A.F., Minna J.D.;
RT   "Analysis of human small cell lung cancer differentiation antigens
RT   using a panel of rat monoclonal antibodies.";
RL   Cancer Res. 44:2052-2061(1984).
RX   PubMed=8626706; DOI=10.1074/jbc.271.19.11477;
RA   Quinn K.A., Treston A.M., Unsworth E.J., Miller M.-J., Vos M.,
RA   Grimley C., Battey J., Mulshine J.L., Cuttitta F.;
RT   "Insulin-like growth factor expression in human cancer cell lines.";
RL   J. Biol. Chem. 271:11477-11483(1996).
RX   PubMed=8806092; DOI=10.1002/jcb.240630505;
RA   Phelps R.M., Johnson B.E., Ihde D.C., Gazdar A.F., Carbone D.P.,
RA   McClintock P.R., Linnoila R.I., Matthews M.J., Bunn P.A. Jr.,
RA   Carney D.N., Minna J.D., Mulshine J.L.;
RT   "NCI-Navy Medical Oncology Branch cell line data base.";
RL   J. Cell. Biochem. 63 Suppl. 24:32-91(1996).
RX   PubMed=8806103; DOI=10.1002/jcb.240630516;
RA   Johnson B.E., Russell E., Simmons A.M., Phelps R.M., Steinberg S.M.,
RA   Ihde D.C., Gazdar A.F.;
RT   "MYC family DNA amplification in 126 tumor cell lines from patients
RT   with small cell lung cancer.";
RL   J. Cell. Biochem. 63 Suppl. 24:210-217(1996).
RX   PubMed=11030152; DOI=10.1038/sj.onc.1203815;
RA   Modi S., Kubo A., Oie H.K., Coxon A.B., Rehmatulla A., Kaye F.J.;
RT   "Protein expression of the RB-related gene family and SV40 large T
RT   antigen in mesothelioma and lung cancer.";
RL   Oncogene 19:4632-4639(2000).
RX   PubMed=31803961; DOI=10.1002/jcb.29564;
RA   Mulshine J.L., Ujhazy P., Antman M., Burgess C.M., Kuzmin I.A.,
RA   Bunn P.A. Jr., Johnson B.E., Roth J.A., Pass H.I., Ross S.M.,
RA   Aldige C.R., Wistuba I.I., Minna J.D.;
RT   "From clinical specimens to human cancer preclinical models -- a journey
RT   the NCI-cell line database-25 years later.";
RL   J. Cell. Biochem. 121:3986-3999(2020).