ID   THP-1 GAS-Luc2
AC   CVCL_A4CD
DR   ATCC; TIB-202-GAS-LUC2
DR   cancercelllines; CVCL_A4CD
DR   Wikidata; Q105511189
CC   Population: Japanese.
CC   Characteristics: Stably expresses firefly luciferase under the control of the gamma-activated site (GAS) promoter (ATCC=TIB-202-GAS-LUC2).
CC   Doubling time: ~72 hours (ATCC=TIB-202-GAS-LUC2).
CC   Sequence variation: Gene fusion; HGNC; HGNC:2457; CSNK2A1 + HGNC; HGNC:13917; DDX39B; Name(s)=CSNK2A1-DDX39B (from parent cell line).
CC   Sequence variation: Gene fusion; HGNC; HGNC:7132; KMT2A + HGNC; HGNC:7136; MLLT3; Name(s)=KMT2A-MLLT3, MLL-MLLT3, MLL-AF9 (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000039648; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg174fs*3 (c.520_545del26); Zygosity=Heterozygous (from parent cell line).
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; P08659; Photinus pyralis firefly-type luciferase (Note=With optimized codon usage for mammalian expression = Luc2).
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; P13249; Streptomyces alboniger pac (PuroR).
CC   Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
ST   Source(s): ATCC=TIB-202-GAS-LUC2
ST   Amelogenin: X,Y
ST   CSF1PO: 11,13
ST   D13S317: 13
ST   D16S539: 11,12
ST   D5S818: 11,12
ST   D7S820: 10
ST   TH01: 8,9.3
ST   TPOX: 8,11
ST   vWA: 16
DI   NCIt; C9163; Childhood acute monocytic leukemia
DI   ORDO; Orphanet_514; Acute monoblastic/monocytic leukemia
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0006 ! THP-1
SX   Male
AG   1Y
CA   Cancer cell line
DT   Created: 12-01-21; Last updated: 14-08-25; Version: 9
//