ID   ZR-75-1 Tam1
AC   CVCL_A4AL
DR   ATCC; CRL-3438
DR   cancercelllines; CVCL_A4AL
DR   Wikidata; Q105511864
RX   PubMed=27378269;
CC   Population: Caucasian.
CC   Doubling time: ~1 week (ATCC=CRL-3438).
CC   Selected for resistance to: ChEBI; CHEBI_41774; Tamoxifen.
CC   Sequence variation: Mutation; HGNC; HGNC:5173; HRAS; Simple; p.Glu162Lys (c.484G>A); ClinVar=VCV001034833; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Leu108Arg (c.323T>G); Zygosity=Homozygous (from parent cell line).
CC   Omics: Genomics; Whole exome sequencing.
CC   Derived from site: Metastatic; Ascites; UBERON=UBERON_0007795.
ST   Source(s): ATCC=CRL-3438
ST   Amelogenin: X
ST   CSF1PO: 10,11
ST   D13S317: 9
ST   D16S539: 11
ST   D5S818: 13
ST   D7S820: 10,11
ST   TH01: 7,9.3
ST   TPOX: 8
ST   vWA: 16,18
DI   NCIt; C4194; Invasive breast carcinoma of no special type
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0588 ! ZR-75-1
SX   Female
AG   63Y
CA   Cancer cell line
DT   Created: 12-01-21; Last updated: 10-04-25; Version: 9
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RX   PubMed=27378269; DOI=10.1186/s12885-016-2452-5; PMCID=PMC4932681;
RA   Kangaspeska, Sara
RA   Hultsch, Susanne
RA   Jaiswal, Alok
RA   Edgren, Henrik
RA   Mpindi, John Patrick
RA   Eldfors, Samuli
RA   Bruck, Oscar
RA   Aittokallio, Tero
RA   Kallioniemi, Olli-Pekka
RT   "Systematic drug screening reveals specific vulnerabilities and
RT   co-resistance patterns in endocrine-resistant breast cancer.";
RL   BMC Cancer 16:378.1-378.17(2016).
//