ID   NCI-H1450
AC   CVCL_A466
SY   H1450; H-1450
DR   cancercelllines; CVCL_A466
DR   Cosmic; 844573
DR   Cosmic; 877222
DR   Cosmic; 877379
DR   Cosmic; 980948
DR   Cosmic; 1021875
DR   Cosmic; 1032418
DR   Cosmic; 1152484
DR   Cosmic; 1239943
DR   Cosmic; 1518100
DR   Cosmic; 2125231
DR   IARC_TP53; 255
DR   Wikidata; Q54907811
RX   PubMed=1312696;
RX   PubMed=1565469;
RX   PubMed=8806092;
RX   PubMed=8806103;
RX   PubMed=9559342;
RX   PubMed=10987304;
RX   PubMed=11030152;
RX   PubMed=11314036;
RX   PubMed=19472407;
RX   PubMed=20557307;
RX   PubMed=20679594;
RX   PubMed=31803961;
CC   Population: Caucasian.
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Leu194Arg (c.581T>G); ClinVar=VCV000376633; Zygosity=Unspecified (PubMed=1312696; PubMed=1565469; PubMed=20557307).
CC   Derived from site: Metastatic; Bone marrow; UBERON=UBERON_0002371.
ST   Source(s): PubMed=20679594
ST   Amelogenin: X
ST   CSF1PO: 11
ST   D13S317: 12,13
ST   D16S539: 12
ST   D5S818: 11
ST   D7S820: 11
ST   TH01: 9.3
ST   TPOX: 8,9
ST   vWA: 17,19
DI   NCIt; C4917; Lung small cell carcinoma
DI   ORDO; Orphanet_70573; Small cell lung cancer
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
OI   CVCL_2640 ! NCI-BL1450
OI   CVCL_A495 ! NCI-H1451
SX   Male
AG   64Y
CA   Cancer cell line
DT   Created: 06-06-12; Last updated: 19-12-24; Version: 23
//
RX   PubMed=19472407; DOI=10.1002/humu.21028; PMCID=PMC2900846;
RA   Blanco, Raquel
RA   Iwakawa, Reika
RA   Tang, Mo-Ying
RA   Kohno, Takashi
RA   Angulo, Barbara
RA   Pio, Ruben
RA   Montuenga, Luis M.
RA   Minna, John D.
RA   Yokota, Jun
RA   Sanchez-Cespedes, Montse
RT   "A gene-alteration profile of human lung cancer cell lines.";
RL   Hum. Mutat. 30:1199-1206(2009).
//
RX   PubMed=20679594; DOI=10.1093/jnci/djq279; PMCID=PMC2935474;
RA   Gazdar, Adi F.
RA   Girard, Luc
RA   Lockwood, William W.
RA   Lam, Wan L.
RA   Minna, John D.
RT   "Lung cancer cell lines as tools for biomedical discovery and
RT   research.";
RL   J. Natl. Cancer Inst. 102:1310-1321(2010).
//
RX   PubMed=31803961; DOI=10.1002/jcb.29564; PMCID=PMC7496084;
RA   Mulshine, James L.
RA   Ujhazy, Peter
RA   Antman, Melissa
RA   Burgess, Christine M.
RA   Kuzmin, Igor A.
RA   Bunn, Paul A. Jr.
RA   Johnson, Bruce E.
RA   Roth, Jack Alan
RA   Pass, Harvey I.
RA   Ross, Sheila M.
RA   Aldige, Carolyn R.
RA   Wistuba, Ignacio Ivan
RA   Minna, John D.
RT   "From clinical specimens to human cancer preclinical models -- a journey
RT   the NCI-cell line database-25 years later.";
RL   J. Cell. Biochem. 121:3986-3999(2020).
//
RX   PubMed=11030152; DOI=10.1038/sj.onc.1203815;
RA   Modi, Sanjay
RA   Kubo, Akihito
RA   Oie, Herbert Kazuto
RA   Coxon, Amy B.
RA   Rehmatulla, Ahad
RA   Kaye, Frederic J.
RT   "Protein expression of the RB-related gene family and SV40 large T
RT   antigen in mesothelioma and lung cancer.";
RL   Oncogene 19:4632-4639(2000).
//
RX   PubMed=1565469;
RA   Bodner, Sara M.
RA   Minna, John D.
RA   Jensen, Sandra M.
RA   D'Amico, Domenico
RA   Carbone, David P.
RA   Mitsudomi, Tetsuya
RA   Fedorko, Joseph
RA   Buchhagen, Dotothy L.
RA   Nau, Marion M.
RA   Gazdar, Adi F.
RA   Linnoila, Ritva Ilona
RT   "Expression of mutant p53 proteins in lung cancer correlates with the
RT   class of p53 gene mutation.";
RL   Oncogene 7:743-749(1992).
//
RX   PubMed=8806103; DOI=10.1002/jcb.240630516;
RA   Johnson, Bruce E.
RA   Russell, Edward
RA   Simmons, Alfreda M.
RA   Phelps, Ruby M.
RA   Steinberg, Seth M.
RA   Ihde, Daniel Carlyle
RA   Gazdar, Adi F.
RT   "MYC family DNA amplification in 126 tumor cell lines from patients
RT   with small cell lung cancer.";
RL   J. Cell. Biochem. Suppl. 24:210-217(1996).
//
RX   PubMed=11314036; DOI=10.1038/sj.onc.1204211;
RA   Forgacs, Eva
RA   Wren, Jonathan D.
RA   Kamibayashi, Craig
RA   Kondo, Masashi
RA   Xu, Xie L.
RA   Markowitz, Sanford David
RA   Tomlinson, Gail E.
RA   Muller, Carolyn Y.
RA   Gazdar, Adi F.
RA   Garner, Harold Ray
RA   Minna, John D.
RT   "Searching for microsatellite mutations in coding regions in lung,
RT   breast, ovarian and colorectal cancers.";
RL   Oncogene 20:1005-1009(2001).
//
RX   PubMed=8806092; DOI=10.1002/jcb.240630505;
RA   Phelps, Ruby M.
RA   Johnson, Bruce E.
RA   Ihde, Daniel Carlyle
RA   Gazdar, Adi F.
RA   Carbone, David P.
RA   McClintock, Patrick R.
RA   Linnoila, Ritva Ilona
RA   Matthews, Mary J.
RA   Bunn, Paul A. Jr.
RA   Carney, Desmond Niall
RA   Minna, John D.
RA   Mulshine, James L.
RT   "NCI-Navy Medical Oncology Branch cell line data base.";
RL   J. Cell. Biochem. Suppl. 24:32-91(1996).
//
RX   PubMed=20557307; DOI=10.1111/j.1349-7006.2010.01622.x; PMCID=PMC11158680;
RA   Iwakawa, Reika
RA   Kohno, Takashi
RA   Enari, Masatoshi
RA   Kiyono, Tohru
RA   Yokota, Jun
RT   "Prevalence of human papillomavirus 16/18/33 infection and p53
RT   mutation in lung adenocarcinoma.";
RL   Cancer Sci. 101:1891-1896(2010).
//
RX   PubMed=9559342; DOI=10.1002/(SICI)1098-2264(199804)21:4<308::AID-GCC4>3.0.CO;2-2;
RA   Virmani, Arvind K.
RA   Fong, Kwun M.
RA   Kodagoda, Dulmini R.
RA   McIntire, Donald
RA   Hung, Jaclyn Y.
RA   Tonk, Vijay
RA   Minna, John D.
RA   Gazdar, Adi F.
RT   "Allelotyping demonstrates common and distinct patterns of chromosomal
RT   loss in human lung cancer types.";
RL   Genes Chromosomes Cancer 21:308-319(1998).
//
RX   PubMed=10987304;
RA   Girard, Luc
RA   Zochbauer-Muller, Sabine
RA   Virmani, Arvind K.
RA   Gazdar, Adi F.
RA   Minna, John D.
RT   "Genome-wide allelotyping of lung cancer identifies new regions of
RT   allelic loss, differences between small cell lung cancer and non-small
RT   cell lung cancer, and loci clustering.";
RL   Cancer Res. 60:4894-4906(2000).
//
RX   PubMed=1312696;
RA   D'Amico, Domenico
RA   Carbone, David P.
RA   Mitsudomi, Tetsuya
RA   Nau, Marion M.
RA   Fedorko, Joseph
RA   Russell, Edward
RA   Johnson, Britt
RA   Buchhagen, Dotothy L.
RA   Bodner, Sara M.
RA   Phelps, Ruby M.
RA   Gazdar, Adi F.
RA   Minna, John D.
RT   "High frequency of somatically acquired p53 mutations in small-cell
RT   lung cancer cell lines and tumors.";
RL   Oncogene 7:339-346(1992).
//