ID   KBM-3
AC   CVCL_A425
SY   KBM3
DR   cancercelllines; CVCL_A425
DR   ChEMBL-Cells; CHEMBL3307847
DR   ChEMBL-Targets; CHEMBL614010
DR   Cosmic; 975260
DR   IARC_TP53; 4651
DR   PubChem_Cell_line; CVCL_A425
DR   Wikidata; Q54899582
RX   DOI=10.1016/B978-0-12-221970-2.50457-5;
RX   PubMed=1568450;
RX   PubMed=1995877;
RX   PubMed=7627932;
CC   Doubling time: 22.9 hours (Note=At 255th passage) (PubMed=1568450).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Arg273His (c.818G>A); ClinVar=VCV000012366; Zygosity=Unspecified (PubMed=7627932).
CC   Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
DI   NCIt; C7463; Acute myelomonocytic leukemia
DI   ORDO; Orphanet_517; Acute myelomonocytic leukemia
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   32Y
CA   Cancer cell line
DT   Created: 06-06-12; Last updated: 05-10-23; Version: 16
//
RX   DOI=10.1016/B978-0-12-221970-2.50457-5;
RA   Drexler H.G.;
RT   "The leukemia-lymphoma cell line factsbook.";
RL   (In) ISBN 9780122219702; pp.1-733; Academic Press; London (2001).
//
RX   PubMed=1568450;
RA   Andersson B.S., Bergerheim U.S.R., Collins V.P., Childs C., Beran M.,
RA   Sen S., Arden K.C., Pathak S., Siciliano M.J., Ost A., Freireich E.J.;
RT   "KBM-3, an in vitro model of human acute myelomonocytic leukemia.";
RL   Exp. Hematol. 20:361-367(1992).
//
RX   PubMed=1995877; DOI=10.1021/jm00106a013;
RA   Farquhar D., Newman R.A., Zuckerman J.E., Andersson B.S.;
RT   "Doxorubicin analogues incorporating chemically reactive
RT   substituents.";
RL   J. Med. Chem. 34:561-564(1991).
//
RX   PubMed=7627932; DOI=10.1016/0165-4608(94)00282-g;
RA   Sen S., Zhou H.-Y., Andersson B.S., Cork A., Freireich E.J.,
RA   Stass S.A.;
RT   "p53 gene mutations with chromosome 17 abnormalities in chronic
RT   myelogenous leukemia blast crisis patients persist in long-term cell
RT   lines but may be acquired in acute myeloid leukemia cells in vitro.";
RL   Cancer Genet. Cytogenet. 82:35-40(1995).
//