ID   HSC-39
AC   CVCL_A385
SY   HSC39
DR   ArrayExpress; E-MTAB-3610
DR   BioGRID_ORCS_Cell_line; 891
DR   cancercelllines; CVCL_A385
DR   Cell_Model_Passport; SIDM00045
DR   CGH-DB; 106-1
DR   CGH-DB; 9001-4
DR   Cosmic; 875904
DR   Cosmic; 876557
DR   Cosmic; 877037
DR   Cosmic; 897522
DR   Cosmic; 922691
DR   Cosmic; 926116
DR   Cosmic; 1223584
DR   Cosmic; 1460703
DR   Cosmic; 1518248
DR   Cosmic; 1571763
DR   Cosmic-CLP; 1322224
DR   DepMap; ACH-002141
DR   EGA; EGAS00001000978
DR   GDSC; 1322224
DR   GEO; GSM1669905
DR   IARC_TP53; 13724
DR   JCRB; JCRB1864
DR   PharmacoDB; HSC39_621_2019
DR   PRIDE; PXD030304
DR   Wikidata; Q54896389
RX   PubMed=1846312;
RX   PubMed=11107048;
RX   PubMed=11543663;
RX   PubMed=15723654;
RX   PubMed=26934957;
RX   PubMed=27397505;
RX   PubMed=30894373;
RX   PubMed=30971826;
RX   PubMed=35839778;
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Part of: COSMIC cell lines project.
CC   Population: Japanese.
CC   Doubling time: 28-30 hours (PubMed=1846312).
CC   Microsatellite instability: Stable (MSS) (Sanger).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Gly245Ser (c.733G>A); ClinVar=VCV000012365; Zygosity=Homozygous (PubMed=11107048; Cosmic-CLP=1322224; DepMap=ACH-002141).
CC   Omics: Genomics; DNA methylation analysis.
CC   Omics: Genomics; Whole exome sequencing.
CC   Omics: Phenotyping; CRISPR screening.
CC   Omics: Phenotyping; Drug screening.
CC   Omics: Proteomics; Quantitative.
CC   Omics: Transcriptomics; Microarray.
CC   Genome ancestry: African=0.43%; Native American=0%; East Asian, North=78.69%; East Asian, South=18.67%; South Asian=0.72%; European, North=1.03%; European, South=0.47% (PubMed=30894373).
CC   Derived from site: Metastatic; Ascites; UBERON=UBERON_0007795.
ST   Source(s): Cosmic-CLP=1322224; JCRB=JCRB1864
ST   Amelogenin: X
ST   CSF1PO: 11
ST   D13S317: 9
ST   D16S539: 9
ST   D5S818: 13 (Cosmic-CLP=1322224)
ST   D5S818: 13,14 (JCRB=JCRB1864)
ST   D7S820: 11,12 (JCRB=JCRB1864)
ST   D7S820: 12 (Cosmic-CLP=1322224)
ST   TH01: 7,9
ST   TPOX: 8
ST   vWA: 14
DI   NCIt; C5250; Gastric signet ring cell adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
OI   CVCL_A386 ! HSC-40A
SX   Male
AG   54Y
CA   Cancer cell line
DT   Created: 06-06-12; Last updated: 10-04-25; Version: 31
CH   CVCL_C7UP ! 39As8
CH   CVCL_D5HX ! HSC-39 PF
//
RX   PubMed=15723654; DOI=10.1111/j.1349-7006.2005.00016.x; PMCID=PMC11160020;
RA   Takada, Hisashi
RA   Imoto, Issei
RA   Tsuda, Hitoshi
RA   Sonoda, Itaru
RA   Ichikura, Takashi
RA   Mochizuki, Hidetaka
RA   Okanoue, Takeshi
RA   Inazawa, Johji
RT   "Screening of DNA copy-number aberrations in gastric cancer cell lines
RT   by array-based comparative genomic hybridization.";
RL   Cancer Sci. 96:100-110(2005).
//
RX   PubMed=1846312;
RA   Yanagihara, Kazuyoshi
RA   Seyama, Toshio
RA   Tsumuraya, Masaru
RA   Kamada, Nanao
RA   Yokoro, Kenjiro
RT   "Establishment and characterization of human signet ring cell gastric
RT   carcinoma cell lines with amplification of the c-myc oncogene.";
RL   Cancer Res. 51:381-386(1991).
//
RX   PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775;
RA   Goncalves, Emanuel
RA   Poulos, Rebecca C.
RA   Cai, Zhao-Xiang
RA   Barthorpe, Syd
RA   Manda, Srikanth S.
RA   Lucas, Natasha
RA   Beck, Alexandra
RA   Bucio-Noble, Daniel
RA   Dausmann, Michael
RA   Hall, Caitlin
RA   Hecker, Michael
RA   Koh, Jennifer
RA   Lightfoot, Howard
RA   Mahboob, Sadia
RA   Mali, Iman
RA   Morris, James
RA   Richardson, Laura
RA   Seneviratne, Akila J.
RA   Shepherd, Rebecca
RA   Sykes, Erin
RA   Thomas, Frances
RA   Valentini, Sara
RA   Williams, Steven G.
RA   Wu, Yang-Xiu
RA   Xavier, Dylan
RA   MacKenzie, Karen L.
RA   Hains, Peter G.
RA   Tully, Brett
RA   Robinson, Phillip James
RA   Zhong, Qing
RA   Garnett, Mathew J.
RA   Reddel, Roger Robert
RT   "Pan-cancer proteomic map of 949 human cell lines.";
RL   Cancer Cell 40:835-849.e8(2022).
//
RX   PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469;
RA   Iorio, Francesco
RA   Knijnenburg, Theo A.
RA   Vis, Daniel J.
RA   Bignell, Graham Robert
RA   Menden, Michael Patrick
RA   Schubert, Michael
RA   Aben, Nanne
RA   Goncalves, Emanuel
RA   Barthorpe, Syd
RA   Lightfoot, Howard
RA   Cokelaer, Thomas
RA   Greninger, Patricia
RA   van Dyk, Ewald
RA   Chang, Han
RA   de Silva, Heshani
RA   Heyn, Holger
RA   Deng, Xian-Ming
RA   Egan, Regina K.
RA   Liu, Qing-Song
RA   Mironenko, Tatiana
RA   Mitropoulos, Xeni
RA   Richardson, Laura
RA   Wang, Jin-Hua
RA   Zhang, Ting-Hu
RA   Moran, Sebastian
RA   Sayols, Sergi
RA   Soleimani, Maryam
RA   Tamborero, David
RA   Lopez-Bigas, Nuria
RA   Ross-Macdonald, Petra
RA   Esteller, Manel
RA   Gray, Nathanael S.
RA   Haber, Daniel Arie
RA   Stratton, Michael Rudolf
RA   Benes, Cyril Henri
RA   Wessels, Lodewyk F.A.
RA   Saez-Rodriguez, Julio
RA   McDermott, Ultan
RA   Garnett, Mathew J.
RT   "A landscape of pharmacogenomic interactions in cancer.";
RL   Cell 166:740-754(2016).
//
RX   PubMed=11107048; DOI=10.1046/j.1440-1827.2000.01117.x;
RA   Yokozaki, Hiroshi
RT   "Molecular characteristics of eight gastric cancer cell lines
RT   established in Japan.";
RL   Pathol. Int. 50:767-777(2000).
//
RX   PubMed=11543663; DOI=10.1006/viro.2001.1071;
RA   Fukuda, Makoto
RA   Ikuta, Kazufumi
RA   Yanagihara, Kazuyoshi
RA   Tajima, Masako
RA   Kuratsune, Hirohiko
RA   Kurata, Takeshi
RA   Sairenji, Takeshi
RT   "Effect of transforming growth factor-beta1 on the cell growth and
RT   Epstein-Barr virus reactivation in EBV-infected epithelial cell
RT   lines.";
RL   Virology 288:109-118(2001).
//
RX   PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675;
RA   Dutil, Julie
RA   Chen, Zhi-Hua
RA   Monteiro, Alvaro N.A.
RA   Teer, Jamie K.
RA   Eschrich, Steven A.
RT   "An interactive resource to probe genetic diversity and estimated
RT   ancestry in cancer cell lines.";
RL   Cancer Res. 79:1263-1273(2019).
//
RX   PubMed=26934957; DOI=10.1038/srep22371; PMCID=PMC4776110;
RA   Kurashige, Junji
RA   Hasegawa, Takanori
RA   Niida, Atsushi
RA   Sugimachi, Keishi
RA   Deng, Nian-Tao
RA   Mima, Kosuke
RA   Uchi, Ryutaro
RA   Sawada, Genta
RA   Takahashi, Yusuke
RA   Eguchi, Hidetoshi
RA   Inomata, Masashi
RA   Kitano, Seigo
RA   Fukagawa, Takeo
RA   Sasako, Mitsuru
RA   Sasaki, Hiroki
RA   Sasaki, Shin
RA   Mori, Masaki
RA   Yanagihara, Kazuyoshi
RA   Baba, Hideo
RA   Miyano, Satoru
RA   Tan, Patrick
RA   Mimori, Koshi
RT   "Integrated molecular profiling of human gastric cancer identifies
RT   DDR2 as a potential regulator of peritoneal dissemination.";
RL   Sci. Rep. 6:22371-22371(2016).
//
RX   PubMed=30971826; DOI=10.1038/s41586-019-1103-9;
RA   Behan, Fiona M.
RA   Iorio, Francesco
RA   Picco, Gabriele
RA   Goncalves, Emanuel
RA   Beaver, Charlotte M.
RA   Migliardi, Giorgia
RA   Santos, Rita
RA   Rao, Yanhua
RA   Sassi, Francesco
RA   Pinnelli, Marika
RA   Ansari, Rizwan
RA   Harper, Sarah
RA   Jackson, David Adam
RA   McRae, Rebecca
RA   Pooley, Rachel
RA   Wilkinson, Piers
RA   van der Meer, Dieudonne J.
RA   Dow, David
RA   Buser-Doepner, Carolyn A.
RA   Bertotti, Andrea
RA   Trusolino, Livio
RA   Stronach, Euan Alexander
RA   Saez-Rodriguez, Julio
RA   Yusa, Kosuke
RA   Garnett, Mathew J.
RT   "Prioritization of cancer therapeutic targets using CRISPR-Cas9
RT   screens.";
RL   Nature 568:511-516(2019).
//