ID   KOPN-32
AC   CVCL_A325
SY   Kopn-32; KOPN32; Kopn32
DR   cancercelllines; CVCL_A325
DR   IARC_TP53; 2681
DR   IARC_TP53; 28433
DR   Wikidata; Q54900301
RX   DOI=10.1016/B978-0-12-221970-2.50457-5;
RX   PubMed=8289498;
RX   PubMed=10360377;
RX   PubMed=10490826;
RX   PubMed=10995006;
RX   PubMed=20575032;
RX   PubMed=35124168;
CC   Population: Japanese.
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Tyr220fs (c.658delT); Zygosity=Unspecified (PubMed=20575032).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Gly245Arg (c.733G>C); ClinVar=VCV000376604; Zygosity=Hemizygous (PubMed=8289498).
CC   Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
DI   NCIt; C9140; Childhood B acute lymphoblastic leukemia
DI   ORDO; Orphanet_99860; Precursor B-cell acute lymphoblastic leukemia
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Sex unspecified
AG   2Y
CA   Cancer cell line
DT   Created: 06-06-12; Last updated: 10-04-25; Version: 19
//
RX   DOI=10.1016/B978-0-12-221970-2.50457-5;
RA   Drexler H.G.;
RT   "The leukemia-lymphoma cell line factsbook.";
RL   (In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001).
//
RX   PubMed=8289498;
RA   Wada H., Asada M., Nakazawa S., Itoh H., Kobayashi Y., Inoue T.,
RA   Fukumuro K., Chan L.C., Sugita K., Hanada R., Akuta N., Kobayashi N.,
RA   Mizutani S.;
RT   "Clonal expansion of p53 mutant cells in leukemia progression in
RT   vitro.";
RL   Leukemia 8:53-59(1994).
//
RX   PubMed=10360377; DOI=10.1038/sj.leu.2401437;
RA   Nakamura M., Sugita K., Inukai T., Goi K., Iijima K., Tezuka T.,
RA   Kojika S., Shiraishi K., Miyamoto N., Karakida N., Kagami K.,
RA   Koyama-Okazaki T., Mori T., Nakazawa S.;
RT   "p16/MTS1/INK4A gene is frequently inactivated by hypermethylation in
RT   childhood acute lymphoblastic leukemia with 11q23 translocation.";
RL   Leukemia 13:884-890(1999).
//
RX   PubMed=10490826; DOI=10.1038/sj.onc.1202874;
RA   Fu X.-Y., McGrath S., Pasillas M.P., Nakazawa S., Kamps M.P.;
RT   "EB-1, a tyrosine kinase signal transduction gene, is
RT   transcriptionally activated in the t(1;19) subset of pre-B ALL, which
RT   express oncoprotein E2a-Pbx1.";
RL   Oncogene 18:4920-4929(1999).
//
RX   PubMed=10995006; DOI=10.1038/sj.leu.2401893;
RA   Iijima K., Sugita K., Inukai T., Goi K., Tezuka T., Uno K., Sato H.,
RA   Kagami K., Nakazawa S.;
RT   "Expression of thrombopoietin receptor and its functional role in
RT   human B-precursor leukemia cells with 11q23 translocation or
RT   Philadelphia chromosome.";
RL   Leukemia 14:1598-1605(2000).
//
RX   PubMed=20575032; DOI=10.1002/ajh.21738; PMCID=PMC7159455;
RA   Inukai T., Zhang X.-R., Kameyama T., Suzuki Y., Yoshikawa K., Kuroda I.,
RA   Nemoto A., Akahane K., Sato H., Goi K., Nakamoto K., Hamada J.-i.,
RA   Tada M., Moriuchi T., Sugita K.;
RT   "A specific linkage between the incidence of TP53 mutations and type
RT   of chromosomal translocations in B-precursor acute lymphoblastic
RT   leukemia cell lines.";
RL   Am. J. Hematol. 85:535-537(2010).
//
RX   PubMed=35124168; DOI=10.1016/j.jsbmb.2022.106068;
RA   Tamai M., Kasai S., Akahane K., Thu T.N., Kagami K., Komatsu C.,
RA   Abe M., Watanabe A., Goi K., Miyake K., Inaba T., Takita J., Goto H.,
RA   Minegishi M., Iwamoto S., Sugita K., Inukai T.;
RT   "Glucocorticoid receptor gene mutations confer glucocorticoid
RT   resistance in B-cell precursor acute lymphoblastic leukemia.";
RL   J. Steroid Biochem. Mol. Biol. 218:106068.1-106068.12(2022).
//