ID   SUP-B7
AC   CVCL_A318
DR   Wikidata; Q54970873
RX   DOI=10.1016/B978-0-12-221970-2.50457-5;
RX   PubMed=1434795;
RX   PubMed=3469019;
RX   PubMed=7630190;
RX   PubMed=7888679;
RX   PubMed=8704231;
RX   PubMed=9108419;
RX   PubMed=9823951;
CC   Doubling time: ~100 hours (PubMed=1434795); 7 days (PubMed=3469019).
CC   Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371.
DI   NCIt; C9140; Childhood B acute lymphoblastic leukemia
DI   ORDO; Orphanet_99860; Precursor B-cell acute lymphoblastic leukemia
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   2Y
CA   Cancer cell line
DT   Created: 06-06-12; Last updated: 29-06-23; Version: 10
//
RX   DOI=10.1016/B978-0-12-221970-2.50457-5;
RA   Drexler H.G.;
RT   "The leukemia-lymphoma cell line factsbook.";
RL   (In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001).
//
RX   PubMed=1434795;
RA   Neely E.K., Rosenfeld R.G., Illescas A., Smith S.D.;
RT   "Mitogenic effects of human recombinant insulin on B-cell precursor
RT   acute lymphoblastic leukemia cells.";
RL   Leukemia 6:1134-1142(1992).
//
RX   PubMed=3469019;
RA   Smith S.D., Morgan R., Galili N., Amylon M.D., Link M.P., Hecht F.,
RA   Sklar J., Glader B.E.;
RT   "Establishment and characterization of a common acute lymphoblastic
RT   leukemia cell line with a deletion of chromosome 3 band q26.";
RL   Cancer Res. 47:1652-1656(1987).
//
RX   PubMed=7630190;
RA   Zhou M.-X., Gu L.-B., James C.D., He J., Yeager A.M., Smith S.D.,
RA   Findley H.W. Jr.;
RT   "Homozygous deletions of the CDKN2 (MTS1/p16ink4) gene in cell lines
RT   established from children with acute lymphoblastic leukemia.";
RL   Leukemia 9:1159-1161(1995).
//
RX   PubMed=7888679; DOI=10.1182/blood.V85.6.1608.bloodjournal8561608;
RA   Zhou M.-X., Yeager A.M., Smith S.D., Findley H.W. Jr.;
RT   "Overexpression of the MDM2 gene by childhood acute lymphoblastic
RT   leukemia cells expressing the wild-type p53 gene.";
RL   Blood 85:1608-1614(1995).
//
RX   PubMed=8704231; DOI=10.1182/blood.V88.3.785.785;
RA   Kim D.-H., Moldwin R.L., Vignon C., Bohlander S.K., Suto Y.,
RA   Giordano L., Gupta R., Fears S., Nucifora G., Rowley J.D., Smith S.D.;
RT   "TEL-AML1 translocations with TEL and CDKN2 inactivation in acute
RT   lymphoblastic leukemia cell lines.";
RL   Blood 88:785-794(1996).
//
RX   PubMed=9108419; DOI=10.1182/blood.V89.8.2986;
RA   Findley H.W. Jr., Gu L.-B., Yeager A.M., Zhou M.-X.;
RT   "Expression and regulation of Bcl-2, Bcl-xl, and Bax correlate with
RT   p53 status and sensitivity to apoptosis in childhood acute
RT   lymphoblastic leukemia.";
RL   Blood 89:2986-2993(1997).
//
RX   PubMed=9823951; DOI=10.1038/sj.leu.2401198;
RA   Zhou M.-X., Gu L.-B., Yeager A.M., Findley H.W. Jr.;
RT   "Sensitivity to Fas-mediated apoptosis in pediatric acute
RT   lymphoblastic leukemia is associated with a mutant p53 phenotype and
RT   absence of Bcl-2 expression.";
RL   Leukemia 12:1756-1763(1998).
//