ID   Hep G2-E43
AC   CVCL_A2HF
SY   Hep G2-Cl2E1-43; HepG2-CYP2E1 E43; E43
DR   cancercelllines; CVCL_A2HF
DR   Wikidata; Q105507625
RX   PubMed=9547353;
RX   PubMed=10748080;
CC   Population: Caucasian.
CC   Characteristics: Overexpresses CYP2E1.
CC   Sequence variation: Mutation; HGNC; 7989; NRAS; Simple; p.Gln61Leu (c.182A>T); ClinVar=VCV000375874; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
CC   Transfected with: HGNC; 2631; CYP2E1.
CC   Transfected with: UniProtKB; P00552; Transposon Tn5 neo.
CC   Derived from site: In situ; Liver; UBERON=UBERON_0002107.
DI   NCIt; C3728; Hepatoblastoma
DI   ORDO; Orphanet_449; Hepatoblastoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0027 ! Hep-G2
SX   Male
AG   15Y
CA   Cancer cell line
DT   Created: 12-01-21; Last updated: 05-10-23; Version: 5
//
RX   PubMed=9547353; DOI=10.1124/mol.53.4.638;
RA   Chen Q., Cederbaum A.I.;
RT   "Cytotoxicity and apoptosis produced by cytochrome P450 2E1 in Hep G2
RT   cells.";
RL   Mol. Pharmacol. 53:638-648(1998).
//
RX   PubMed=10748080; DOI=10.1074/jbc.M907022199;
RA   Mari M., Cederbaum A.I.;
RT   "CYP2E1 overexpression in HepG2 cells induces glutathione synthesis by
RT   transcriptional activation of gamma-glutamylcysteine synthetase.";
RL   J. Biol. Chem. 275:15563-15571(2000).
//