ID   GP64
AC   CVCL_A2FM
DR   ABM; T0867
DR   Wikidata; Q105507470
RX   PubMed=33100283;
CC   Characteristics: Expresses kisspeptin and ER-alpha both at the mRNA and protein levels and responds to estrogen, similar to endogenous preoptic area kisspeptin neurons, which mediate estrogen positive feedback and regulate GnRH/LH surge (PubMed=33100283).
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; P03070; SV40 large T antigen.
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; P00552; Transposon Tn5 neo.
CC   Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40).
CC   Derived from site: In situ; Fetal brain, hypothalamus, preoptic area; UBERON=UBERON_0006238+UBERON_0001928.
CC   Cell type: Kisspeptin neuron; CL=CL_4023130.
CC   Breed/subspecies: Shiba; VBO=VBO_0017514.
OX   NCBI_TaxID=9925; ! Capra hircus (Goat)
OI   CVCL_A2FJ ! GA28
OI   CVCL_A2FK ! GP11
OI   CVCL_A2FL ! GP31
SX   Female
AG   118FD
CA   Transformed cell line
DT   Created: 12-01-21; Last updated: 19-12-24; Version: 9
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RX   PubMed=33100283; DOI=10.1262/jrd.2020-053; PMCID=PMC7902218;
RA   Oshimo Y., Munetomo A., Magata F., Suetomi Y., Sonoda S., Takeuchi Y.,
RA   Tsukamura H., Ohkura S., Matsuda F.;
RT   "Estrogen increases KISS1 expression in newly generated immortalized
RT   KISS1-expressing cell line derived from goat preoptic area.";
RL   J. Reprod. Dev. 67:15-23(2021).
//