ID   KCL040
AC   CVCL_A273
SY   KCL-040
DR   ISCR; 1894
DR   NIHhESC; NIHhESC-14-0272
DR   Wikidata; Q54899688
RX   PubMed=23161805;
RX   PubMed=26607962;
RX   PubMed=27345807;
RX   PubMed=28445466;
WW   https://www.kcl.ac.uk/lsm/research/divisions/wh/groups/medicine/hescell.aspx
CC   Group: Clinical grade pluripotent cell line.
CC   From: King's College London; London; United Kingdom.
CC   Registration: NIH Human Embryonic Stem Cell Registry; NIHhESC-14-0272.
CC   Registration: UK Stem Cell Bank (UKSCB); Steering comm. appl. SCSC12-37.
CC   HLA typing: A*03,24; B*07,15; C*03,07; DRB1*04:04/23/42/56/0,15 (PubMed=23161805).
CC   Omics: CNV analysis.
CC   Omics: Deep exome analysis.
CC   Omics: SNP array analysis.
CC   Derived from site: In situ; Blastocyst; UBERON=UBERON_0000358.
CC   Cell type: Embryonic stem cell; CL=CL_0002322.
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   Blastocyst stage
CA   Embryonic stem cell
DT   Created: 06-06-12; Last updated: 02-05-24; Version: 20
//
RX   PubMed=23161805; DOI=10.1002/emmm.201201973;
RA   Jacquet L., Stephenson E.L., Collins R., Patel H., Trussler J.,
RA   Al-Bedaery R., Renwick P., Ogilvie C.M., Vaughan R., Ilic D.;
RT   "Strategy for the creation of clinical grade hESC line banks that
RT   HLA-match a target population.";
RL   EMBO Mol. Med. 5:10-17(2013).
//
RX   PubMed=26607962; DOI=10.1038/srep17258;
RA   Canham M.A., Van Deusen A.L., Brison D.R., De Sousa P.A., Downie J.M.,
RA   Devito L.G., Hewitt Z.A., Ilic D., Kimber S.J., Moore H.D., Murray H.,
RA   Kunath T.;
RT   "The molecular karyotype of 25 clinical-grade human embryonic stem
RT   cell lines.";
RL   Sci. Rep. 5:17258-17258(2015).
//
RX   PubMed=27345807; DOI=10.1016/j.scr.2015.12.035;
RA   Jacquet L., Wood V., Kadeva N., Cornwell G., Codognotto S.,
RA   Stephenson E.L., Ilic D.;
RT   "Generation of KCL040 clinical grade human embryonic stem cell line.";
RL   Stem Cell Res. 16:173-176(2016).
//
RX   PubMed=28445466; DOI=10.1038/nature22312;
RA   Merkle F.T., Ghosh S., Kamitaki N., Mitchell J., Avior Y., Mello C.,
RA   Kashin S., Mekhoubad S., Ilic D., Charlton M., Saphier G.,
RA   Handsaker R.E., Genovese G., Bar S., Benvenisty N., McCarroll S.A.,
RA   Eggan K.C.;
RT   "Human pluripotent stem cells recurrently acquire and expand dominant
RT   negative P53 mutations.";
RL   Nature 545:229-233(2017).
//