ID   HT-144 Dab-R/Tram-R
AC   CVCL_A1VL
SY   HT144_Dab_Tram; HT144 SKIN FV3; HT144SKINFV3
DR   cancercelllines; CVCL_A1VL
DR   DepMap; ACH-002459
DR   Wikidata; Q105509486
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Population: Caucasian.
CC   Selected for resistance to: ChEBI; CHEBI:75045; Dabrafenib (Tafinlar; GSK2118436).
CC   Selected for resistance to: ChEBI; CHEBI:75998; Trametinib (Mekinist; GSK1120212).
CC   Sequence variation: Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Gene deletion; HGNC; 9588; PTEN; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Homozygous (DepMap=ACH-002459).
CC   Sequence variation: Mutation; HGNC; 11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
CC   Derived from site: Metastatic; Hypodermis; UBERON=UBERON_0002072.
DI   NCIt; C3224; Melanoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0318 ! HT-144
SX   Male
AG   29Y
CA   Cancer cell line
DT   Created: 12-01-21; Last updated: 02-05-24; Version: 7
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