ID   MAgEC 11.5
AC   CVCL_A1AY
SY   Mouse Aorta gonad mesonephros Endothelial Cells 11.5 dpc
DR   Wikidata; Q102114496
RX   Patent=US9631178;
RX   PubMed=26577811;
CC   Group: Patented cell line.
CC   Registration: International Depositary Authority, Pasteur Institute Collection Nationale de Cultures de Micro-organismes (CNCM); I-4223.
CC   Characteristics: Displays progenitor endothelial characteristics. Is more differentiated than MAgEC 10.5 (Cellosaurus=CVCL_A1AY) and displays faster angiogenesis in vitro, different response to hypoxia and chemokines (PubMed=26577811).
CC   Doubling time: ~24 hours (PubMed=26577811).
CC   Transfected with: UniProtKB; P00552; Transposon Tn5 neo.
CC   Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40).
CC   Derived from site: In situ; Embryonic aorta-gonad-mesonephros; UBERON=UBERON_0003105.
CC   Cell type: Endothelial cell of aorta; CL=CL_0002544.
CC   Breed/subspecies: FVB.
OX   NCBI_TaxID=10090; ! Mus musculus (Mouse)
AG   10-11FD
CA   Transformed cell line
DT   Created: 29-10-20; Last updated: 29-06-23; Version: 5
//
RX   Patent=US9631178;
RA   Kieda C., Grillon C., Lamerant-Fayel N., Paprocka M., Krawczenko A.,
RA   Dus D.;
RT   "Human and murine stem-cell lines: models of endothelial cell
RT   precursors.";
RL   Patent number US9631178, 25-Apr-2017.
//
RX   PubMed=26577811; DOI=10.1016/j.canlet.2015.11.008;
RA   Collet G., Szade K., Nowak W.N., Klimkiewicz K., El Hafny-Rahbi B.,
RA   Szczepanek K., Sugiyama D., Weglarczyk K., Foucault-Collet A.,
RA   Guichard A., Mazan A., Nadim M., Fasani F., Lamerant-Fayel N.,
RA   Grillon C., Petoud S., Beloeil J.-C., Jozkowicz A., Dulak J.,
RA   Kieda C.;
RT   "Endothelial precursor cell-based therapy to target the pathologic
RT   angiogenesis and compensate tumor hypoxia.";
RL   Cancer Lett. 370:345-357(2016).
//