ID   ZMAC-4
AC   CVCL_A0XV
SY   ZMAC1107-4; Zuckermann MACrophage-4
DR   Wikidata; Q108821563
RX   Patent=US9169465;
RX   PubMed=21191013;
RX   PubMed=32515659;
CC   Characteristics: CSF1 dependent.
CC   Virology: Susceptible to infection by porcine reproductive and respiratory syndrome virus (PRRSV) (PubMed=21191013).
CC   Virology: Supports high level of replication of African swine fever virus attenuated strain OURT88/3 (PubMed=32515659).
CC   Doubling time: 3.9 +- 0.3 days (PubMed=32515659).
CC   Derived from site: In situ; Fetal lung, alveolus; UBERON=UBERON_0005597+UBERON_0002299.
CC   Cell type: Alveolar macrophage; CL=CL_0000583.
CC   Breed/subspecies: Landrace x Yorkshire x Duroc.
OX   NCBI_TaxID=9823; ! Sus scrofa (Pig)
SX   Sex unspecified
AG   60FD
CA   Factor-dependent cell line
DT   Created: 23-09-21; Last updated: 29-06-23; Version: 6
//
RX   Patent=US9169465;
RA   Zuckermann F.A.;
RT   "Non-simian cells for growth of porcine reproductive and respiratory
RT   syndrome (PRRS) virus.";
RL   Patent number US9169465, 27-Oct-2015.
//
RX   PubMed=21191013; DOI=10.1128/JVI.01616-10;
RA   Calzada-Nova G., Schnitzlein W.M., Husmann R.J., Zuckermann F.A.;
RT   "North American porcine reproductive and respiratory syndrome viruses
RT   inhibit type I interferon production by plasmacytoid dendritic
RT   cells.";
RL   J. Virol. 85:2703-2713(2011).
//
RX   PubMed=32515659; DOI=10.1080/22221751.2020.1772675;
RA   Portugal R., Goatley L.C., Husmann R.J., Zuckermann F.A., Dixon L.K.;
RT   "A porcine macrophage cell line that supports high levels of
RT   replication of OURT88/3, an attenuated strain of African swine fever
RT   virus.";
RL   Emerg. Microbes Infect. 9:1245-1253(2020).
//